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首页> 外文期刊>Drug research >Effects of rolipram and zaprinast on learning and memory in the morris water maze and radial arm maze tests in naive mice
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Effects of rolipram and zaprinast on learning and memory in the morris water maze and radial arm maze tests in naive mice

机译：咯利普兰和扎普利斯特对莫里斯水迷宫和radial臂迷宫试验对学习和记忆的影响

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摘要

Inhibition of phosphodiesterase 5 (PDE) improved recognition memory and counteracted spatial learning impairment induced by nitric oxide synthase (NOS) inhibition in recent studies. Aim of this study was to investigate effects of rolipram, a PDE4 inhibitor and zaprinast, a PDE5 inhibitor, on learning and memory in Morris water maze (MWM) and radial arm maze (RAM) tests in naive mice. Male Balb-c mice were treated subchronically with zaprinast (3 and 10 mg/kg) and rolipram (0.05 and 0.1 mg/kg) for 6 days in the MWM test and acutely before the retention trial of radial arm maze test. Rolipram (0.05 and 0.1 mg/kg) significantly decreased escape latency between 2nd and 5th sessions, while zaprinast (10 mg/kg) significantly decreased escape latency only in 2nd session. Rolipram (0.05 and 0.1 mg/kg) and zaprinast (10 mg/kg) significantly increased time spent in escape platform's quadrant in probe trial of MWM test; only rolipram decreased mean distance to platform, while zaprinast had no effect on mean distance to platform. Zaprinast (3 and 10 mg/kg) significantly decreased number of errors compared to control group, while rolipram (0.05 and 0.1 mg/kg) had no effect on number of errors in retention trial of RAM test. Rolipram (0.05 and 0.1 mg/kg) and zaprinast (10 mg/kg) significantly decreased time spent to complete retention trial (latency) compared to control group. Our study revealed that both zaprinast and rolipram enhanced spatial memory in MWM, while zaprinast seems to have more memory enhancing effects compared to rolipram in radial arm maze test.
机译：在最近的研究中，磷酸二酯酶5（PDE）的抑制改善了识别记忆，并抵消了由一氧化氮合酶（NOS）抑制引起的空间学习障碍。这项研究的目的是研究莫立斯水迷宫（MWM）和radial臂迷宫（RAM）测试中的PDE4抑制剂rolipram和PDE5抑制剂za​​prinast对学习和记忆的影响。在MWM测试中，以及在radial臂迷宫测试的保留试验之前，先对雄性Balb-c小鼠进行亚扎非司特（3和10 mg / kg）和咯利普兰（0.05和0.1 mg / kg）亚慢性治疗6天。咯利普兰（0.05和0.1 mg / kg）显着降低了第2次和第5次会议之间的逃避潜伏期，而扎普利纳特（10 mg / kg）仅在第2次会议中显着降低了逃避潜伏期。在MWM测试的探针试验中，咯利普兰（0.05和0.1 mg / kg）和扎普利斯特（10 mg / kg）显着增加了逃逸平台象限所花费的时间;只有咯利普兰降低了与平台的平均距离，而扎普利那斯特对平台的平均距离没有影响。与对照组相比，Zaprinast（3和10 mg / kg）显着减少了错误数，而咯利普兰（0.05和0.1 mg / kg）对RAM测试的保留试验中的错误数没有影响。与对照组相比，Rolipram（0.05和0.1 mg / kg）和zaprinast（10 mg / kg）显着减少了完成保留试验的时间（潜伏期）。我们的研究表明，zaprinast和rolipram在MWM中均增强了空间记忆，而在radial臂迷宫测试中，zaprinast与rolipram相比似乎具有更多的记忆增强作用。

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