Photocontrol of cell adhesion processes: Model studies with cyclic azobenzene-RGD peptides

Schutt M.; Krupka SS.; Milbradt AG.; Deindl S.; Sinner EK.; Oesterhelt D. Renner C.; Moroder L.

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Photocontrol of cell adhesion processes: Model studies with cyclic azobenzene-RGD peptides

机译：细胞粘附过程的光控制：环偶氮苯-RGD肽的模型研究

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A photoresponsive integrin ligand was synthesized by backbone-cyclization of a heptapeptide containing the integrin binding motif Arg-Gly-Asp (RGD) with 4-(aminomethyl)phenylazobenzoic acid (AMPB). Surface plasmon enhanced fluorescence spectroscopy showed that binding of the azobenzene peptide to alpha(v)beta(3) integrin depends on the photoisomeric state of the peptide chromophore. The higher affinity of the trans isomer could be rationalized by comparing the NMR conformations of the cis and trans isomers with the recently solved X-ray structure of a cyclic RGD-pentapeptide bound to integrin. [References: 32]

机译：通过将含有整联蛋白结合基序Arg-Gly-Asp（RGD）的七肽与4-（氨基甲基）苯基偶氮苯甲酸（AMPB）进行主链环化，合成了光响应整联蛋白配体。表面等离子体增强荧光光谱表明，偶氮苯肽与α（v）β（3）整联蛋白的结合取决于肽发色团的光异构状态。反式异构体的较高亲和力可以通过比较顺式和反式异构体的NMR构象与最近解析的与整联蛋白结合的环状RGD-五肽的X射线结构来合理化。 [参考：32]

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《Chemistry & biology》 |2003年第6期|共4页
作者
Schutt M.; Krupka SS.; Milbradt AG.; Deindl S.; Sinner EK.; Oesterhelt D. Renner C.; Moroder L.;
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正文语种 eng
中图分类化学;
关键词
Conformational states; Backbone constituent; Selective inhibitors; Bicyclic peptides; Helix content; Integrins; Photomodulation; Receptors; Acid; Alpha-v-beta-3;

机译：构象态;骨干成分;选择性抑制剂;双环肽;螺旋含量;整联蛋白;光调节;受体;酸;Alpha-v-beta-3;

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1. Photocontrol of cell adhesion processes: Model studies with cyclic azobenzene-RGD peptides [J] . Schutt M., Krupka SS., Milbradt AG., Chemistry & biology . 2003,第6期

机译：细胞粘附过程的光控制：环偶氮苯-RGD肽的模型研究
2. Effect of Mechanical Environment of Focal Adhesions on Remodeling of Endothelial Cells Subjected to Cyclic Stretching Using Microsubstrates [J] . Naoya Sakamoto, Yoshimasa Yamazaki, Toshiro Ohashi, Journal of robotics and mechatronics . 2007,第5期

机译：局部黏附的机械环境对使用微底物循环拉伸的内皮细胞重构的影响
3. Dennexin peptides modeled after the homophilic binding sites of the neural cell adhesion molecule (NCAM) promote neuronal survival, modify cell adhesion and impair spatial learning [J] . Kohler Lene B., Christensen Claus, Rossetti Clara, European Journal of Cell Biology: Journal of Deutsche Gesellschaft fur Elektronenmikroskopie: Journal of Deutsche Gesellschaft fur Zellbiologie . 2010,第11期

机译：在神经细胞粘附分子（NCAM）的同源结合位点之后建模的Dennexin肽促进神经元存活，改变细胞粘附并损害空间学习
4. Use of Supported Thin Films of Peptide Amphiphiles as Model Systems of The Extracellular Matrix to Study the Effects of Structure-Function Phenomena on Cell Adhesion [C] . Matthew Tirrell, Sarah Ochsenhirt, Gregg B. Fields PMSE Symposia . 2003

机译：使用支撑薄膜的肽两亲物作为细胞外基质的模型系统，研究结构功能现象对细胞粘附的影响
5. I. Selection, synthesis, and mechanisms studies of cell-penetrating peptides: New drug delivery systems. II. Biological lessons for the preparation of Abeta(1-42) and cyclic peptide probe for the detection of botulinum neurotoxin A. [D] . Kim, YoungSoo. 2006

机译：I.细胞穿透肽的选择，合成和机理研究：新药物递送系统。二。制备Abeta（1-42）和用于检测肉毒杆菌神经毒素A的环肽探针的生物学课程。
6. A specific affinity cyclic peptide enhances the adhesion expansion and proliferation of rat bone mesenchymal stem cells on β-tricalcium phosphate scaffolds [O] . Tiantong Sun, Zhentao Man, Changliang Peng, -1

机译：特异性亲和环肽可增强大鼠骨间充质干细胞在β-磷酸三钙支架上的粘附扩增和增殖
7. Photocontrol of Cell Adhesion Processes Model Studies with Cyclic Azobenzene-RGD Peptides [O] . Schütt Markus, Krupka Simone S, Milbradt Alexander G, 2003

机译：环偶氮苯-RGD肽对细胞粘附过程的光控制模型研究

Photocontrol of cell adhesion processes: Model studies with cyclic azobenzene-RGD peptides

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