What causes some patients with drug-induced QT interval prolongation to develop torsades de pointes but not others? The elusive missing link

TisdaleJ.E.

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What causes some patients with drug-induced QT interval prolongation to develop torsades de pointes but not others? The elusive missing link

机译：是什么原因导致某些药物引起的QT间隔延长的患者发展成尖端扭转型室速而不是其他患者？难以捉摸的缺失链接

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Cardiac arrest due to torsades de pointes (TdP) is an uncommon but potentially catastrophic event associated with QT interval-prolonging drugs [1], Numerous medications that may cause TdP are available for use in clinical practice, and include drugs for management of cardiovascular diseases, primarily arrhythmias, but also noncardio-vascular agents from multiple classes, including anti-infectives, antipsychotics, antidepressants, methadone, and many more [2]. The risk of TdP increases as the heart rate-corrected QT (QTC) interval increases [3-6], particularly when it exceeds 500 ms [5, 6].

机译：尖端扭转型室速（TdP）引起的心脏骤停是罕见的，但可能与QT间期延长药物有关[1]。具有多种可能导致TdP的药物可用于临床，包括用于治疗心血管疾病的药物，主要是心律不齐，也包括多种类别的非心血管药物，包括抗感染药，抗精神病药，抗抑郁药，美沙酮等[2]。随着心率校正QT（QTC）间隔的增加，TdP的风险也会增加[3-6]，尤其是当其超过500 ms时[5，6]。

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《Drugs and aging》 |2014年第8期|共3页
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TisdaleJ.E.;
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1. What causes some patients with drug-induced QT interval prolongation to develop torsades de pointes but not others? The elusive missing link [J] . TisdaleJ.E. Drugs and aging . 2014,第8期

机译：是什么原因导致某些药物引起的QT间隔延长的患者发展成尖端扭转型室速而不是其他患者？难以捉摸的缺失链接
2. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit. [J] . Jacobson I, Carlsson L, Duker G Journal of Pharmacological and Toxicological Methods . 2011,第1期

机译：逐搏QT间期变异性，但QT延长本身无统计学意义，预示了麻醉的甲氧胺致敏兔子的药物诱发的扭转性扭转性发作。
3. The effect of intravenous haloperidol on QT interval dispersion in critically ill patients: comparison with QT interval prolongation for assessment of risk of Torsades de Pointes. [J] . Tisdale JE, Rasty S, Padhi ID, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2001,第12期

机译：静脉注射氟哌啶醇对危重患者QT间期离散度的影响：与QT间期延长的比较以评估尖锐湿疣的风险。
4. Drug-Induced Torsade de Pointes. Role of Genetic Factors [C] . N. EL SHERIF, G. TURITTO International Workshop on Cardiac Arrhythmias . 2004

机译：药物引起的扭转de指向。遗传因素的作用
5. Potential mechanisms for drug-induced prolongation of QT interval and genesis of torsades de pointes evaluated in the failing rabbit heart. [D] . Kijtawornrat, Anusak. 2007

机译：在衰竭的心脏中评估了药物引起的QT间隔延长和扭转性扭转的潜在机制。
6. Drug-induced QT interval prolongation and torsades de pointes [O] . James E. Tisdale 2016

机译：药物诱导的QT间隔延长和扭转
7. What Causes Some Patients with Drug-Induced QT Interval Prolongation to Develop Torsades de Pointes but Not Others? The Elusive Missing Link [O] . James E. Tisdale 2014

机译：是什么导致一些药物诱导的Qt间隔延长的患者发展扭曲，但不是其他人？难以捉摸的缺失链接
8. Q-T-Interval in Relatie tot Totale, Cardiovasculaire en IschaemischeHartziektesterfte: Een Prospektieve Studie onder Amsterdamse Ambtenaren (QT-Interval Prolongation Predicts Cardiovascular Mortality in the General Population) [R] . Meppelink, P. 1990

机译：Q-T-Interval in Relatie tot Totale，Cardiovasculaire en IschaemischeHartziektesterfte：Een prospektieve studie onder amsterdamse ambtenaren（QT-Interval延长预测一般人群中的心血管死亡率）

What causes some patients with drug-induced QT interval prolongation to develop torsades de pointes but not others? The elusive missing link

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