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首页> 外文期刊>Drug and alcohol dependence >EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study.
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EEG spectral phenotypes: heritability and association with marijuana and alcohol dependence in an American Indian community study.

机译：脑电图谱表型：在美国印第安人社区研究中的遗传性以及与大麻和酒精依赖的关系。

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Native Americans have some of the highest rates of marijuana and alcohol use and abuse, yet neurobiological measures associated with dependence on these substances in this population remain unknown. The present investigation evaluated the heritability of spectral characteristics of the electroencephalogram (EEG) and their correlation with marijuana and alcohol dependence in an American Indian community. Participants (n=626) were evaluated for marijuana (MJ) and alcohol (ALC) dependence, as well as other psychiatric disorders. EEGs were collected from six cortical sites and spectral power determined in five frequency bands (delta 1.0-4.0 Hz, theta 4.0-7.5 Hz, alpha 7.5-12.0 Hz, low beta 12.0-20.0 Hz and high beta/gamma 20-50 Hz). The estimated heritability (h(2)) of the EEG phenotypes was calculated using SOLAR, and ranged from 0.16 to 0.67. Stepwise linear regression was used to detect correlations between MJ and ALC dependence and the spectral characteristics of the EEG using a model that took into account: age, gender, Native American Heritage (NAH) and a lifetime diagnosis of antisocial personality and/or conduct disorder (ASPD/CD). Increases in spectral power in the delta frequency range, were significantly correlated with gender (p<0.001) and marijuana dependence (p<0.003). Gender, age, NAH and ASPD/CD were all significantly (p<0.001) correlated with theta, alpha and beta band power, whereas alcohol dependence (p<0.01), gender (p<0.001), and ASPD/CD (p<0.001) were all correlated with high beta/gamma band power. These data suggest that the traits of EEG delta and high beta/gamma activity are correlated with MJ dependence and alcohol dependence, respectively, in this community sample of Native Americans.
机译：美洲印第安人的大麻和酒精使用和滥用率最高，但是与依赖这些物质的神经生物学措施在该人群中的关系仍然未知。本研究评估了美国印第安人社区中脑电图（EEG）频谱特征的遗传性及其与大麻和酒精依赖的相关性。对参与者（n = 626）的大麻（MJ）和酒精（ALC）依赖性以及其他精神疾病进行了评估。从六个皮质位点收集脑电图，并在五个频带（δ1.0-4.0 Hz，θ4.0-7.5 Hz，α7.5-12.0 Hz，低β12.0-20.0 Hz和高β/γ20-50 Hz）中确定频谱功率。使用SOLAR计算EEG表型的估计遗传力（h（2）），范围为0.16至0.67。使用考虑以下因素的模型，使用逐步线性回归来检测MJ和ALC依赖性与EEG频谱特征之间的相关性：年龄，性别，美国原住民传统（NAH）以及终身反社会人格和/或行为障碍诊断（ASPD / CD）。三角频率范围内频谱功率的增加与性别（p <0.001）和大麻依赖（p <0.003）显着相关。性别，年龄，NAH和ASPD / CD均与theta，α和β谱带功率显着相关（p <0.001），而酒精依赖（p <0.01），性别（p <0.001）和ASPD / CD（p < 0.001）都与高β/γ带功率相关。这些数据表明，在该美洲原住民社区样本中，EEGδ和高β/γ活性的特征分别与MJ依赖和酒精依赖相关。

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