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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >CXCR4 overexpression during the course of HIV-1 infection correlates with the emergence of X4 strains.
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CXCR4 overexpression during the course of HIV-1 infection correlates with the emergence of X4 strains.

机译：HIV-1感染过程中CXCR4过表达与X4菌株的出现有关。

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摘要

The factors that determine the emergence of X4 isolates in some HIV-1-infected subjects are unknown. As the level of expression of CXCR4 could favor an R5 to X4 switch, quantitative flow cytometry was used to measure CXCR4 density on CD4 T cells in 200 HIV-1-positive adults, and this was compared with CD4 counts, interleukin-7 (IL-7), and RANTES (regulated on activation, normal T expressed and secreted) plasma levels and the R5/X4 virus phenotype. CD4 T-cell surface CXCR4 densities were increased in infected subjects and inversely correlated with CD4 T-cell count (r=-0.548, P<0.001). Yet, in vitro infection with either R5 or X4 strains and in vivo increases in viral load following interruption of antiretroviral treatment did not induce CXCR4 overexpression. The plasma levels of IL-7 and RANTES, 2 cytokines able to induce CXCR4 expression, did not correlate with CXCR4 density. Finally, higher CXCR4 densities were observed in patients harboring X4 strains (3300, 95% CI 2431-4169 CXCR4 molecules per cell)than in patients harboring only R5 strains (2406, 95% CI 2135-2677, P=0.027). These data suggest that CXCR4 overexpression during the course of the disease in some patients could favor the emergence of X4 strains.
机译：决定在某些感染HIV-1的受试者中X4分离株出现的因素尚不清楚。由于CXCR4的表达水平可能支持R5到X4的转换，因此使用定量流式细胞术来测量200名HIV-1阳性成年人中CD4 T细胞上的CXCR4密度，并将其与CD4计数，白介素7（IL -7）和RANTES（受激活，正常T表达和分泌的调节）血浆水平和R5 / X4病毒表型。 CD4 T细胞表面CXCR4密度在受感染的受试者中增加，并且与CD4 T细胞计数呈负相关（r = -0.548，P <0.001）。然而，R5或X4菌株的体外感染以及抗逆转录病毒治疗中断后体内病毒载量的增加并未诱导CXCR4过表达。能够诱导CXCR4表达的2种细胞因子IL-7和RANTES的血浆水平与CXCR4密度无关。最后，与仅携带R5菌株的患者（2406，95％CI 2135-2677，P = 0.027）相比，携带X4菌株的患者（3300，95％CI 2431-4169 CXCR4分子/细胞）观察到更高的CXCR4密度。这些数据表明，在某些患者的病程中，CXCR4的过度表达可能有利于X4菌株的出现。

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