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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Predominance of a rare type of HIV-1 in Estonia.
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Predominance of a rare type of HIV-1 in Estonia.

机译：在爱沙尼亚，一种罕见的HIV-1类型占主导地位。

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摘要

An earlier study has indicated that a complex recombinant HIV-1 strain dominates the epidemic in Estonia. The objective of this study was to further investigate the molecular epidemiology and genetic structure of HIV-1 in Estonia. Most of the investigated individuals became infected after August 2000 when HIV-1 started to spread rapidly among Estonian intravenous drug users (IDUs). Two viral DNA regions, gag/pol and gp41, were sequenced and subtyped from peripheral blood mononuclear cells or plasma from 141 individuals. Phylogenetic analysis in the gp41 region revealed that the most frequent type of the virus among IDUs was a circulating recombinant form, CRF06_cpx, whereas a few samples showed highest sequence similarity to a subtype A strain circulating in Ukraine and Russia. Likewise, in the gag/pol region, most of the samples were classified as CRF06_cpx, with a few classified as subtype A. In this region, however, 16% of the sequences turned out to be mosaic unique recombinant forms consisting of CRF06_cpx and subtype A. At least 9 mosaic forms were identified, each with distinct patterns of multiple crossover. To characterize Estonian CRF06_cpx as well as recombinant isolates in more detail, 4 near-full-length HIV-1 genomes were sequenced.
机译：一项较早的研究表明，复杂的重组HIV-1菌株在爱沙尼亚流行中占主导地位。这项研究的目的是进一步调查爱沙尼亚HIV-1的分子流行病学和遗传结构。在2000年8月之后，当HIV-1开始在爱沙尼亚的静脉吸毒者（IDU）中迅速传播时，大多数被调查者被感染。从141个个体的外周血单核细胞或血浆中对两个病毒DNA区域gag / pol和gp41进行了测序和亚型化。 gp41区的系统发育分析表明，IDU中最常见的病毒类型是循环的重组形式CRF06_cpx，而少数样品显示与在乌克兰和俄罗斯传播的A型亚型菌株具有最高的序列相似性。同样，在gag / pol区域中，大多数样品被分类为CRF06_cpx，少数样品被分类为A亚型。但是，在该区域中，有16％的序列被证明是由CRF06_cpx和亚型组成的镶嵌独特重组形式答：至少确定了9种镶嵌形式，每种都有不同的多重交叉模式。为了更详细地表征爱沙尼亚CRF06_cpx以及重组分离株，对4个近乎全长的HIV-1基因组进行了测序。

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