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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Presence of HIV-Specific CD4+ T-Cell Responses in HIV-Infected Subjects With Sustained Virologic Control After Highly Active Antiretroviral Therapy.
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Presence of HIV-Specific CD4+ T-Cell Responses in HIV-Infected Subjects With Sustained Virologic Control After Highly Active Antiretroviral Therapy.

机译：高度抗病毒治疗后，具有持续病毒学控制的HIV感染受试者中存在HIV特异性CD4 + T细胞应答。

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: HIV-specific CD4 T-helper cell responses in 40 subjects with chronic infection (CI) who had virus suppression after highly active antiretroviral therapy (HAART) were compared with those in 34 subjects treated during primary infection (PI). A CD4 T-cell proliferative response to HIV p24 protein was present in 50% of these subjects compared with 79% of subjects treated during PI. The existence of a proliferative response in CI subjects was associated with a higher CD4 T-cell count at initiation of HAART, a longer duration of virus suppression, and a higher CD4 T-cell count at the time of analysis. These results show that an HIV-specific proliferative response is preferentially observed in treated CI subjects with CD4 T-cell counts of >200/microL. However, in treated CI subjects with a significant degree of CD4 T-cell depletion (<200/microL), it may also be observed in 35% provided that the duration of virus suppression is long enough, which may have implications for future therapeutic strategies.
机译：：将40例在积极抗逆转录病毒治疗（HAART）后受到病毒抑制的慢性感染（CI）受试者中HIV特异性CD4 T辅助细胞反应与在初次感染（PI）期间接受治疗的34例受试者进行了比较。在这些受试者中有50％出现了对HIV p24蛋白的CD4 T细胞增殖反应，而在PI期间接受治疗的受试者只有79％。 CI受试者中增殖反应的存在与HAART启动时CD4 T细胞计数较高，病毒抑制持续时间较长以及分析时CD4 T细胞计数较高相关。这些结果表明，在CD4 T细胞计数> 200 / microL的已治疗CI受试者中，优先观察到HIV特异性增殖反应。但是，在患有严重CD4 T细胞耗竭（<200 / microL）的已治疗CI受试者中，如果病毒抑制的持续时间足够长，也可能会以35％的比例观察到，这可能对将来的治疗策略产生影响。

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