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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Increased circulating interleukin-7 levels in HIV-1-infected women.
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Increased circulating interleukin-7 levels in HIV-1-infected women.

机译:HIV-1感染妇女的循环白细胞介素7水平升高。

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摘要

Sex-based differences in CD4 T-cell (CD4) counts are well recognized, but the basis for these differences has not been identified. Conceivably, homeostatic factors may play a role in this process by regulating T-cell maintenance and repletion. Interleukin (IL)-7 is essential for normal T-cell production and homeostasis. We hypothesized that differences in IL-7 might contribute to sex-based differences in CD4 counts. Circulating IL-7 levels were analyzed in 299 HIV-1-infected women and men. Regression analysis estimated that IL-7 levels were 40% higher in women than in men (P = 0.0032) after controlling for CD4 count, age, and race. Given the important role of IL-7 in T-cell development and homeostasis, these findings suggest that higher IL-7 levels may contribute to higher CD4 counts in women.
机译:众所周知,基于性别的CD4 T细胞(CD4)计数存在差异,但尚未确定这些差异的基础。可以想象,体内平衡因素可能通过调节T细胞的维持和补充在这一过程中发挥作用。白细胞介素(IL)-7对于正常T细胞产生和体内平衡至关重要。我们假设IL-7的差异可能会导致基于性别的CD4计数差异。在299名HIV-1感染的男女中分析了循环中的IL-7水平。回归分析估计,在控制了CD4的数量,年龄和种族之后,女性的IL-7水平比男性高40%(P = 0.0032)。鉴于IL-7在T细胞发育和体内平衡中的重要作用,这些发现表明,较高的IL-7水平可能有助于女性增加CD4计数。

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