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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Comparison of mother-to-child transmission rates in Ugandan women with subtype A versus D HIV-1 who received single-dose nevirapine prophylaxis: HIV Network For Prevention Trials 012.
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Comparison of mother-to-child transmission rates in Ugandan women with subtype A versus D HIV-1 who received single-dose nevirapine prophylaxis: HIV Network For Prevention Trials 012.

机译：接受单剂奈韦拉平预防的A型和D型亚型HIV-1乌干达妇女母婴传播率比较：HIV预防网络012。

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摘要

OBJECTIVE: To compare the rate of mother-to-child transmission (MTCT) in women with subtype A versus D HIV-1 who received single-dose nevirapine (NVP). METHODS: The MTCT rates were compared in women with subtype A versus D at birth and at 8 weeks and 18 months of age of the infants. The rate of late MTCT (after 8 weeks of age) was also analyzed. RESULTS: HIV-1 subtypes were determined for 300 of 306 women who received NVP in the HIV Network for Prevention Trials 012 study (158 women with subtype A and 105 women with subtype D). Infant infection status was known for 297 women. The cumulative rate of MTCT at 18 months was 13.2% for subtype A and 18.3% for subtype D (P=0.34). The rate of late transmission was 3.8% for subtype A and 7.6% for subtype D (P=0.28). Maternal baseline viral load was a significant predictor of MTCT, but maternal baseline CD4 cell count and subtype were not. CONCLUSIONS: No significant difference was observed in the rate of MTCT in women with subtype A versus D. There was a trend toward a higher rate of MTCT among women with subtype D, however, which was also apparent among women whose infants were infected after 8 weeks of age.
机译：目的：比较接受单剂量奈韦拉平（NVP）治疗的A型和D型HIV-1亚型女性的母婴传播（MTCT）率。方法：比较了出生时以及婴儿8周和18个月时A型和D型亚型女性的MTCT率。还分析了晚期MTCT（8周龄后）的发生率。结果：在HIV预防试验网络012研究中，为306名接受NVP的女性中的300名确定了HIV-1亚型（158名A型女性和105名D型女性）。已知297名妇女的婴儿感染状况。亚型A在18个月时的MTCT累积率为13.2％，而D型则为18.3％（P = 0.34）。 A型亚型和D型亚型的晚期传播率为3.8％（P = 0.28）。母体基线病毒载量是MTCT的重要预测指标，但母体基线CD4细胞计数和亚型则不是。结论：A型和D型女性的MTCT发生率没有显着差异。但是，D型女性的MTCT有增加的趋势，但是，婴儿在8岁以后被感染的女性中也很明显。周龄。

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