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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >French national sentinel survey of antiretroviral drug resistance in patients with HIV-1 primary infection and in antiretroviral-naive chronically infected patients in 2001-2002.
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French national sentinel survey of antiretroviral drug resistance in patients with HIV-1 primary infection and in antiretroviral-naive chronically infected patients in 2001-2002.

机译：法国国家哨兵调查2001-2002年HIV-1原发感染患者和未接受过抗逆转录病毒治疗的慢性感染患者的抗逆转录病毒药物耐药性。

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摘要

OBJECTIVE: To survey the frequency of genotypic antiretroviral resistance and the spread of non-B subtypes in patients with primary HIV-1 infection (2001-2002) and in treatment-naive chronically HIV-1-infected patients (2001). METHODS: Plasma samples from 303 patients with acute HIV-1 infection (Primo study) and 363 treatment-naive patients with chronic HIV-1 infection (Odyssee study) were tested for genotypic resistance. Resistance mutations were identified from the International AIDS Society Resistance Testing-USA panel and resistant viruses were defined according to the French Agence Nationale de Recherches sur le SIDA (ANRS) resistance algorithm. RESULTS: In the Primo study, 14% of the patients had viruses with resistance mutations and 12% of patients had viruses with mutations conferring resistance to least 1 antiretroviral drug. Thirty patients had viruses with mutations to at least 1 antiretroviral drug in a single pharmacologic class. Six patients were infected by viruses resistant to 2 or 3 classes of drugs. In the Odyssee study, the prevalence of reverse transcript (RT) associated and major protease inhibitor-associated mutations was 6.1% (95% CI: 3.6-8.6). Six patients had viruses resistant to at least 1 antiretroviral drug and 3 patients had viruses resistant to 2 classes of antiretroviral drugs. Twenty-four percent of acutely infected patients harbored non-B subtype strains (19% in 1999-2000) and 33.2% of chronically infected patients (10% in 1998; P < 0.0001). CONCLUSION: In France, the frequency of HIV-1 resistance in untreated patients was not significantly higher in 2001-2002 than in previous surveys while the prevalence of non-B subtypes is increasing.
机译：目的：调查原发性HIV-1感染者（2001-2002）和未接受过治疗的慢性HIV-1感染者（2001）的基因型抗逆转录病毒耐药性的频率和非B亚型的传播。方法：对303名急性HIV-1感染患者的血浆样本（Primo研究）和363名未接受过治疗的慢性HIV-1感染患者（Odyssee研究）进行了基因型耐药性测试。从美国国际艾滋病学会抗药性测试小组中鉴定出抗药性突变，并根据法国SIDA全国抗药性（ANRS）抗药性算法定义抗药性病毒。结果：在Primo研究中，有14％的患者具有耐药突变的病毒，而12％的患者具有赋予至少一种抗逆转录病毒药物耐药的突变的病毒。 30名患者的病毒在单一药理学类别中具有至少一种抗逆转录病毒药物突变的病毒。六名患者感染了对2或3类药物具有抗性的病毒。在Odyssee研究中，逆转录（RT）相关和主要蛋白酶抑制剂相关突变的患病率为6.1％（95％CI：3.6-8.6）。六名患者的病毒对至少一种抗逆转录病毒药物有抵抗力，三名患者的病毒对两种抗逆转录病毒药物有抵抗力。急性感染患者中有24％携带非B亚型病毒株（1999-2000年为19％），慢性感染患者为33.2％（1998年为10％; P <0.0001）。结论在法国，未经治疗的患者中HIV-1耐药的频率在2001-2002年没有比以前的调查显着增加，而非B型亚型的患病率却在增加。

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