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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Epidemiological data of different human papillomavirus genotypes in cervical specimens of HIV-1-infected women without history of cervical pathology.
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Epidemiological data of different human papillomavirus genotypes in cervical specimens of HIV-1-infected women without history of cervical pathology.

机译：没有宫颈病理史的HIV-1感染妇女宫颈标本中不同人乳头瘤病毒基因型的流行病学数据。

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AIM: To study the epidemiology of different human papillomavirus (HPV) genotypes in cervical samples of HIV-1-infected women with normal Papanicolau smears. DESIGN:: Retrospective analysis of a prospective cohort. PATIENTS AND METHODS: We selected HIV-1-infected women with 2 consecutive normal Papanicolau smears at baseline and at least 1 baseline and 1 follow-up cervical sample. HPV infection was assessed by second-generation hybrid capture (HC-2) and multiplex polymerase chain reaction (mPCR). HPV genotypes were determined by mPCR. RESULTS: From a cohort of 139 women followed up to 4 years, 93 women meeting the inclusion criteria were analyzed. The mean period between samples was 20 months (range, 6-44 months). HPV baseline prevalence was 63% [59/93; 95% confidence interval (CI), 53% to 73%] using polymerase chain reaction and 41% (38/93; 95% CI, 31% to 51%) using HC-2, P = 0.007 (kappa, 0.45; P = 0.001). The most prevalent high oncogenic risk genotypes (HR-HPV) were HPV-16 (28%), HPV-33 (18%), HPV-52 (12%), HPV-58 (11%), and HPV-39 (11%). Infection with multiple HPV genotypes was detected in >40% of women. HPV infection persisted at follow-up in 86% (51/59; 95% CI, 77% to 95%) by polymerase chain reaction and 76% (29/38; 95% CI, 62% to 90%) by HC-2. HPV infection persisted in 55% of women with samples available beyond 3 years. The actuarial probabilities of clearance and incidence of HPV infection at 36 months were 16% and 45%, respectively. CONCLUSIONS: HPV infection is highly prevalent and persistent among HIV-1-infected women with normal Papanicolau smears. HR-HPV genotypes other than HPV-16 (HPV-33, HPV-52) are frequently detected in HIV-infected women. mPCR provides better surveillance of HPV infection than HC-2 methods.
机译：目的：研究在正常帕潘尼古劳涂片被HIV-1感染的妇女的宫颈样本中不同人乳头瘤病毒（HPV）基因型的流行病学。设计：：对预期队列的回顾性分析。病人和方法：我们选择感染HIV-1的妇女，她们在基线时连续2次正常帕潘尼古劳涂片，至少有1条基线和1例随访宫颈样本。通过第二代杂交捕获（HC-2）和多重聚合酶链反应（mPCR）评估HPV感染。 HPV基因型通过mPCR确定。结果：从139名随访至4年的女性队列中，分析了93名符合纳入标准的女性。样本之间的平均时间为20个月（6-44个月）。 HPV基线患病率为63％[59/93;使用聚合酶链反应的置信区间（CI）为95％（53％至73％），使用HC-2则为41％（38/93; 95％CI为31％至51％），P = 0.007（kappa，0.45; P = 0.001）。最流行的高致癌风险基因型（HR-HPV）为HPV-16（28％），HPV-33（18％），HPV-52（12％），HPV-58（11％）和HPV-39（ 11％）。在> 40％的女性中发现了多种HPV基因型感染。随访发现，HPV感染通过聚合酶链反应持续持续在86％（51/59; CI：77％至95％）和HC-76％（29/38; 95％CI，62％至90％）。 2。 HPV感染在55％的女性中持续存在，样本超过3年可用。在36个月时清除HPV和感染HPV的发生率的精算概率分别为16％和45％。结论：HPV感染在帕潘尼古劳涂片正常的HIV-1感染妇女中高度流行和持续。在感染HIV的女性中经常发现HPV-16（HPV-33，HPV-52）以外的HR-HPV基因型。与HC-2方法相比，mPCR提供了更好的HPV感染监测。

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