...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Pediatric HIV-1 in Kenya: pattern and correlates of viral load and association with mortality.
【24h】

Pediatric HIV-1 in Kenya: pattern and correlates of viral load and association with mortality.

机译：肯尼亚的小儿HIV-1：病毒载量的模式及其相关性和与死亡率的关系。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: There is limited information regarding the pattern and correlates of viral replication in vertically HIV-1-infected children and its role on their outcomes in resource-limited settings. METHODS: HIV-1-infected infants were followed from birth to 24 months. Serial HIV-1 RNA levels were compared in infants infected in utero (<48 hours), peripartum (48 hours-1 month), and late postnatal (after 1 month). Cofactors for viral peak [highest viral load (VL) within 6 months of infection] and set point and mortality were determined. RESULTS: Among 85 HIV-1-infected infants, 24 were infected in utero, 41 peripartum, 13 late postnatal; 7 had no 48-hour assay. HIV-1 VL set point was significantly lower in infants infected >1 month vs. < or = 1 month (5.59 vs. 6.24 log10 copies per milliliter, P = 0.01). Maternal VL correlated with peak infant VL (P < 0.001). Univariately, infant peak and set point VL and 6-month CD4% <15% predicted mortality; and 6-month CD4% <15% remained independently predictive in multivariate analyses (hazard ratio = 4.85, 95% confidence interval: 1.90 to 12.36). CONCLUSIONS: Infants infected after the age of 1 month contained virus better than infants infected before 1 month of age. Maternal VL predicted infant VL, which, in turn was associated with early mortality.
机译：背景：关于垂直感染HIV-1的儿童中病毒复制的模式和相关性及其在资源有限的环境中对他们结局的作用的信息有限。方法：从出生至24个月随访HIV-1感染的婴儿。比较了在子宫内（<48小时），围产期（48小时-1个月）和产后晚期（1个月后）感染的婴儿的HIV-1 RNA序列水平。确定了病毒峰值[感染后6个月内最高病毒载量（VL）]，设定点和死亡率的辅助因子。结果：在85名被HIV-1感染的婴儿中，有24名在子宫内被感染，41名围产期，在出生后13名被感染。 7个没有进行48小时检测。感染> 1个月与<或= 1个月的婴儿相比，HIV-1 VL设定点显着降低（5.59 vs 6.24 log10拷贝/毫升，P = 0.01）。孕妇VL与婴儿VL峰值相关（P <0.001）。婴儿峰值和设定点VL和6个月CD4％<15％的预测死亡率均是一致的;在多变量分析中，6个月CD4％<15％仍然是独立的预测因素（危险比= 4.85，95％置信区间：1.90至12.36）。结论：1个月后感染的婴儿比1个月前感染的婴儿病毒更好。孕妇VL可预测婴儿VL，而婴儿VL则与早期死亡相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号