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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >Estimation of the predictive role of plasma viral load on CD4 decline in HIV-1 subtype C-infected subjects in India.
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Estimation of the predictive role of plasma viral load on CD4 decline in HIV-1 subtype C-infected subjects in India.

机译：在印度，HIV-1亚型C感染受试者的血浆病毒载量对CD4下降的预测作用的估计。

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BACKGROUND: Plasma viral load has been shown to be a meaningful prognostic marker for disease progression in untreated, HIV-1 subtype B-infected subjects in United States and Western Europe and therefore used as a prognostic marker for disease progression. Because of high expenses of commercially available viral load assays, the role of viral load in disease progression has not been evaluated in HIV-1 subtype C-infected patients in India. METHODS: We developed an inexpensive real-time reverse transcriptase-polymerase chain reaction assay to quantify viral load in plasma of HIV-1 subtype C-infected subjects from India and used it in a longitudinal analysis of viral load and CD4 cell number in HIV-infected subjects from Calcutta, India. RESULTS: The real-time reverse transcriptase-polymerase chain reaction assay can quantify plasma viral load with a linear range of detection from 10 to 10 HIV-1 RNA copies per input. Longitudinal analysis of viral load in a cohort of 39 subjects over an average period of approximately 3 years indicates that 1-log increase in HIV-1 RNA level was associated with a decline of 67 CD4 cell count. Furthermore, HIV-1 RNA level between 500 and 50,000 copies per milliliter would predict a 12.9% decrease in CD4 cell count per year, whereas HIV-1 RNA levels above 50,000 copies HIV-1 RNA per milliliter would predict a 25.3% decrease in CD4 cells per year. In addition, we estimated that the mean incubation period of disease development, as defined by the loss of CD4 below 200, is 8.2 years. CONCLUSION: Our report on the level of viral load on predicting CD4 decline in Indian subjects with HIV-1 provides an additional important tool to the physicians for treating and planning a therapeutic strategy to control HIV-1 infection in India.
机译：背景：在美国和西欧，血浆病毒载量已被证明是未经治疗的HIV-1 B型亚型感染受试者中疾病进展的有意义的预后标志物，因此被用作疾病进展的预后标志物。由于市售病毒载量测定的费用高昂，因此尚未在印度的HIV-1亚型C感染患者中评估病毒载量在疾病进展中的作用。方法：我们开发了一种廉价的实时逆转录酶-聚合酶链反应测定法，以量化来自印度的HIV-1亚型C感染受试者的血浆中的病毒载量，并将其用于纵向分析HIV-中的病毒载量和CD4细胞数来自印度加尔各答的感染者。结果：实时逆转录聚合酶链反应法可定量检测血浆病毒载量，线性检测范围为每个输入10至10个HIV-1 RNA拷贝。在大约3年的平均时间内对39名受试者的病毒载量进行了纵向分析，结果表明HIV-1 RNA水平上升1个对数与67个CD4细胞计数的下降有关。此外，每毫升500至50,000拷贝之间的HIV-1 RNA水平可预测每年CD4细胞计数下降12.9％，而每毫升50,000拷贝以上的HIV-1 RNA水平可预测CD4细胞下降25.3％。每年。此外，我们估计疾病发展的平均潜伏期（定义为200以下的CD4损失）为8.2年。结论：我们关于预测印度HIV-1感染者CD4下降的病毒载量水平的报告为医生提供了另一重要工具，以帮助医生制定计划在印度控制HIV-1感染的治疗策略。

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