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首页> 外文期刊>JAIDS: Journal of acquired immune deficiency syndromes >A Randomized Treatment Trial: Single Versus 7-Day Dose of Metronidazole for The Treatment of Trichomonas Vaginalis Among HIV-lnfected Women
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A Randomized Treatment Trial: Single Versus 7-Day Dose of Metronidazole for The Treatment of Trichomonas Vaginalis Among HIV-lnfected Women

机译：随机治疗试验：甲硝唑单剂与7天剂量一起治疗HIV感染妇女的滴虫性阴道炎

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Objective: To determine if the metronidazole (MTZ) 2-gm single dose (recommended) is as effective as the 7-day 500 mg twice a day dose (alternative) for treatment of Trichomonas vaginalis (TV) among HIV+ women.Methods: Phase IV randomized clinical trial; HFV+ women with culture confirmed TV were randomized to treatment arm: MTZ 2-gm single dose or MTZ 500 mg twice a day 7-day dose. All women were given 2-gm MTZ doses to deliver to their sex partners. Women were recultured for TV at a test-of-cure (TOC) visit occurring 6-12 days after treatment completion. TV-negative women at TOC were again recultured at a 3-month visit. Repeat TV infection rates were compared between arms.Results: Two hundred seventy HIV+/TV+ women were enrolled (mean age = 40 years, +-9.4; 92.2% African American). Treatment arms were similar with respect to age, race, CD4 count, viral load, antiretroviral therapy status, site, and loss-to-follow up. Women in the 7-day arm had lower repeat TV infection rates at TOC [8.5% (11 of 130) versus 16.8% (21 of 125) (relative risk: 0.50, 95% confidence interval = 0.25, 1.00; P < 0.05)] and at 3 months [11.0% (8 of 73) versus 24.1% (19 of 79) (relative risk: 0.46, 95% confidence interval = 0.21, 0.98; P = 0.03)] compared with the single-dose arm.Conclusions: The 7-day MTZ dose was more effective than the single dose for the treatment of TV among HTV+ women.
机译：目的：确定2毫克甲硝唑（MTZ）单次剂量（推荐）是否与7天500毫克每日两次剂量（替代）在HIV +妇女中治疗阴道毛滴虫（TV）一样有效。 IV随机临床试验; HFV +经文化确认电视的妇女被随机分配至治疗组：MTZ 2克单次剂量或MTZ 500毫克，每日两次，每天7天。所有妇女均服用2克MTZ剂量以分娩至性伴侣。在治疗完成后的6至12天进行一次测试（TOC）访视，对妇女进行电视培养。在3个月的访问中，TOC的电视阴性女性再次进行了培养。比较两组之间重复电视感染的比率。结果：招募了270名HIV + / TV +妇女（平均年龄= 40岁，+-9.4; 92.2％的非洲裔美国人）。在年龄，种族，CD4计数，病毒载量，抗逆转录病毒疗法的状态，部位和随访失败方面，治疗组相似。接受7天治疗的女性在TOC时的重复电视感染率较低[8.5％（130名中的11名）和16.8％（125名中的21名）（相对危险度：0.50、95％置信区间= 0.25、1.00; P <0.05） ]和在3个月时[11.0％（73的8）对24.1％（79的19]）（相对风险：0.46，95％置信区间= 0.21，0.98; P = 0.03）]。 ：在HTV +妇女中，为期7天的MTZ剂量比单剂量更有效。

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