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首页> 外文期刊>JACC. Cardiovascular imaging. >Clinical characteristics, vascular function, and inflammation in women with angina in the absence of coronary atherosclerosis: the Dallas Heart Study.
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Clinical characteristics, vascular function, and inflammation in women with angina in the absence of coronary atherosclerosis: the Dallas Heart Study.

机译：在没有冠状动脉粥样硬化的情况下患有心绞痛的女性的临床特征，血管功能和炎症：《达拉斯心脏研究》。

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OBJECTIVES: we sought to evaluate the relationship between angina and coronary artery calcium (CAC) in women, and among women without CAC, the associations between angina and clinical, vascular, and inflammatory factors. BACKGROUND: angina in women without coronary atherosclerosis is associated with significant morbidity, yet its determinants are poorly understood. METHODS: women ages 30 to 65 years from the Dallas Heart Study, a multiethnic probability sample of Dallas County residents, who completed a Rose angina questionnaire and had complete data for CAC by computed tomography were selected for this analysis. Soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, high sensitivity C-reactive protein, monocyte chemoattractant protein-1 and aortic compliance by magnetic resonance imaging were measured. RESULTS: among the 1,480 women in this cohort (mean age 45 years, 49% African-American), angina was present in 6.9% but was not associated with CAC (19% CAC prevalence with angina vs. 15% without, p = 0.2). Among women without CAC, angina was related to variables reflecting obesity and insulin resistance and was independently associated with African-American ethnicity, premature family history of myocardial infarction, and waist circumference (all p < 0.05). Such women with angina also had higher levels of soluble intercellular adhesion molecule-1 (668 vs. 592 ng/ml, p = 0.02) and soluble vascular cell adhesion molecule-1 (1,106 vs. 968 ng/ml, p = 0.01) and reduced aortic compliance (mean 22 vs. 26 ml/mm Hg, p = 0.007) than such women without angina. Conversely, there was no difference in C-reactive protein or monocyte chemoattractant protein-1 levels for women with and without angina (p = not significant, each). CONCLUSIONS: angina among women in the general population is common and is not associated with subclinical atherosclerosis. Additionally, angina in the absence of subclinical atherosclerosis is not related to many traditional atherosclerotic risk factors but is associated with clinical, inflammatory, and vascular factors that reflect endothelial dysfunction and vascular stiffness, suggesting a distinct vascular etiology and alternative potential therapeutic targets.
机译：目的：我们试图评估女性和非CAC女性心绞痛与冠状动脉钙（CAC）之间的关系，心绞痛与临床，血管和炎症因子之间的关系。背景：没有冠状动脉粥样硬化的女性的心绞痛与明显的发病率有关，但对其决定因素了解甚少。方法：从达拉斯心脏研究（达拉斯县居民的多族裔概率样本）中选取30至65岁的女性作为样本，他们完成了玫瑰心绞痛问卷并通过计算机断层摄影获得了CAC的完整数据。通过磁共振成像测量了可溶性细胞间粘附分子-1，可溶性血管细胞粘附分子-1，高灵敏度C反应蛋白，单核细胞趋化蛋白-1和主动脉顺应性。结果：在该队列的1,480名妇女中（平均年龄45岁，占49％的非洲裔美国人），心绞痛的发生率为6.9％，但与CAC无关（心绞痛的CAC患病率为19％，无心绞痛的为15％，p = 0.2）。 ）。在没有CAC的女性中，心绞痛与反映肥胖和胰岛素抵抗的变量有关，并且与非裔美国人种族，心肌梗死的家族史和腰围独立相关（所有p <0.05）。患有心绞痛的女性的可溶性细胞间粘附分子1（668 vs. 592 ng / ml，p = 0.02）和可溶性血管细胞粘附分子1（1,106 vs. 968 ng / ml，p = 0.01）的水平也较高。与没有心绞痛的女性相比，主动脉顺应性降低（平均22 vs. 26 ml / mm Hg，p = 0.007）。相反，患有和不患有心绞痛的女性的C反应蛋白或单核细胞趋化蛋白1水平没有差异（p =均不显着）。结论：普通人群中女性的心绞痛很常见，与亚临床动脉粥样硬化无关。此外，不存在亚临床动脉粥样硬化的心绞痛与许多传统的动脉粥样硬化危险因素无关，但与反映内皮功能障碍和血管僵硬的临床，炎性和血管因素相关，表明存在独特的血管病因和其他潜在的治疗靶点。

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