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首页> 外文期刊>JACC. Cardiovascular imaging. >Quantification of myocardial segmental function in acute and chronic ischemic heart disease and implications for cardiovascular cell therapy trials: a review from the NHLBI-Cardiovascular Cell Therapy Research Network.
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Quantification of myocardial segmental function in acute and chronic ischemic heart disease and implications for cardiovascular cell therapy trials: a review from the NHLBI-Cardiovascular Cell Therapy Research Network.

机译：NHLBI-心血管细胞治疗研究网络的回顾，对急性和慢性缺血性心脏病中心肌节段功能的量化及其对心血管细胞治疗试验的意义。

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Global left ventricular (LV) ejection fraction (LVEF) has been used as a measure of improvement in LV function following cell therapy. Although the impact of cell therapy on LVEF in short- and long-term follow-up has been generally positive, there is concern that research evaluating regional therapeutics (e.g., cell or gene therapy) may require analysis of regional LV function localized to the site of intervention. Regional LV assessment is traditionally performed with qualitative or quantitative analysis of wall thickening within 16 myocardial segments, but advances in noninvasive imaging permit an increasingly more detailed and accurate evaluation of LV function. Wall-thickness measurements can now include evaluation of over 1,000 myocardial segments. In addition to higher resolution measures of wall thickening, automated assessments of myocardial segment deformation, such as strain imaging, exist. Strain imaging allows for direct evaluation of the mechanical properties that may improve following regional therapeutic intervention. Improvements in regional LV function may also be assessed by determining regional ejection fraction (EF). Regional EF offers the advantage of summarizing the end result of all of the complex deformations in the adjacent myocardial segments. Although regional EF and strain imaging, as compared with wall thickening, enhance detection of improvement in complex measures of regional myocardial function, it remains unclear whether such measures are better able to predict meaningful improvement in clinical outcomes.
机译：整体左心室射血分数（LVEF）已被用作衡量细胞治疗后左室功能改善的指标。尽管短期和长期随访中细胞疗法对LVEF的影响总体上是积极的，但人们担心评估区域疗法（例如细胞或基因疗法）的研究可能需要分析定位于该部位的区域LV功能的干预。传统上，区域性LV评估是通过对16个心肌节段内壁增厚的定性或定量分析来进行的，但是无创成像技术的进步使LV功能的评估越来越详细和准确。壁厚测量现在可以包括对1,000多个心肌节段的评估。除了更高分辨率的壁增厚措施外，还存在对心肌节段变形的自动评估，例如应变成像。应变成像可以直接评估机械性能，该机械性能可以在区域性治疗干预后得到改善。还可以通过确定区域射血分数（EF）来评估区域左室功能的改善。区域性EF的优点是总结了相邻心肌节段中所有复杂变形的最终结果。尽管与壁增厚相比，区域性EF和应变显像可增强对区域性心肌功能复杂指标改善的检测，但尚不清楚此类指标是否能够更好地预测临床结果的有意义的改善。

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