Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury

Papa Linda; Brophy Gretchen M.; Welch Robert D.; Lewis Lawrence M.; Braga Carolina F.; Tan Ciara N.; Ameli Neema J.; Lopez Marco A.; Haeussler Crystal A.; Giordano Diego I. Mendez; Silvestri Salvatore; Giordano Philip; Weber Kurt D.; Hill-Pryor Crystal; Hack Dallas C.

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Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury

机译：创伤性轻度和非轻度颅脑损伤大患者队列中神经胶质和神经元血液生物标志物GFAP和UCH-L1的时程和诊断准确性

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IMPORTANCE Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been widely studied and show promise for clinical usefulness in suspected traumatic brain injury (TBI) and concussion. Understanding their diagnostic accuracy over time will help translate them into clinical practice.

机译：重要胶质纤维酸性蛋白（GFAP）和泛素C末端水解酶L1（UCH-L1）已被广泛研究，并显示出可疑的颅脑外伤（TBI）和脑震荡的临床应用前景。随着时间的推移了解它们的诊断准确性将有助于将它们转化为临床实践。

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《JAMA neurology》 |2016年第5期|共10页
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Papa Linda; Brophy Gretchen M.; Welch Robert D.; Lewis Lawrence M.; Braga Carolina F.; Tan Ciara N.; Ameli Neema J.; Lopez Marco A.; Haeussler Crystal A.; Giordano Diego I. Mendez; Silvestri Salvatore; Giordano Philip; Weber Kurt D.; Hill-Pryor Crystal; Hack Dallas C.;
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正文语种 eng
中图分类神经病学与精神病学;
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1. Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury [J] . Papa Linda, Brophy Gretchen M., Welch Robert D., JAMA neurology . 2016,第5期

机译：创伤性轻度和非轻度颅脑损伤大患者队列中神经胶质和神经元血液生物标志物GFAP和UCH-L1的时程和诊断准确性
2. Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive, subconcussive and non-concussive trauma: a prospective cohort study [J] . Linda Papa, Mark R Zonfrillo, Robert D Welch, BMJ paediatrics open. . 2019,第1期

机译：评价脑胶质和神经元血液生物标志物GFAP和UCH-L1作为脑震荡，脑震荡和非脑震荡中脑损伤的梯度：一项前瞻性队列研究
3. Diagnostic accuracy of prehospital serum S100B and GFAP in patients with mild traumatic brain injury: a prospective observational multicenter cohort study – “the PreTBI I study” [J] . Seidenfaden Sophie-Charlott, Kjerulff Julie Linding, Juul Niels, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine . 2021,第1期

机译：温和创伤性脑损伤患者前血清S100B和GFAP的诊断准确性：一项前瞻性观察多中心队列研究 - “我学习的Pretbi”
4. Mining ventricular cerebrospinal fluid from patients with traumatic brain injury using hexapeptide ligand libraries to search for trauma biomarkers [C] . Marcus Sjodin, Jonas Bergquist, Magnus Wetterhall American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：使用六肽配体文库从创伤性脑损伤患者采矿室性脑脊髓液，以寻找创伤生物标志物
5. Cognitive Sequelae of Trauma: Memory and Attention Deficits in Individuals Diagnosed with Posttraumatic Stress Disorder, Mild Traumatic Brain Injury, and Comorbid Posttraumatic Stress Disorder/Mild Traumatic Brain Injury. [D] . Freece, Krista L. 2011

机译：创伤的认知后遗症：被诊断为创伤后应激障碍，轻度创伤性脑损伤和合并症的创伤后应激障碍/轻度创伤性脑损伤的个体的记忆力和注意力不足。
6. Original article: Evaluating glial and neuronal blood biomarkers GFAP and UCH-L1 as gradients of brain injury in concussive subconcussive and non-concussive trauma: a prospective cohort study [O] . Linda Papa, Mark R Zonfrillo, Robert D Welch, 2019

机译：原始文章：评价脑胶质和神经元血液生物标志物GFAP和UCH-L1作为脑震荡脑震荡和非脑震荡中脑损伤的梯度：一项前瞻性队列研究
7. Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury [O] . Linda Papa, Gretchen M. Brophy, Robert D. Welch, 2016

机译：胶质和神经元血液生物标志物GFAP和UCH-L1的时间课程和诊断准确性，在患有轻微创伤性脑损伤的胎粪患者的大队列中

Time Course and Diagnostic Accuracy of Glial and Neuronal Blood Biomarkers GFAP and UCH-L1 in a Large Cohort of Trauma Patients With and Without Mild Traumatic Brain Injury

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