SYNTHESIS OF NEW 1,3,8-TRISUBSTITUTED PURINE-2,6-DIONES AND 1,3,6-TRISUBSTITUTED THIAZOLO[2,3-f]PURINE-2,4-DIONES

Alaa M.Hayallah; Michael Famulok

首页> 外文期刊>Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry >SYNTHESIS OF NEW 1,3,8-TRISUBSTITUTED PURINE-2,6-DIONES AND 1,3,6-TRISUBSTITUTED THIAZOLO[2,3-f]PURINE-2,4-DIONES

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SYNTHESIS OF NEW 1,3,8-TRISUBSTITUTED PURINE-2,6-DIONES AND 1,3,6-TRISUBSTITUTED THIAZOLO[2,3-f]PURINE-2,4-DIONES

机译：合成新的1,3,8-三取代嘌呤-2,6-二酮和1,3,6-三取代的噻唑并[2,3-f] PURINE-2,4-二酮

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New 1,3,8-trisubstituted purine-2,6-diones and 1,3,6-trisubstituted thia-zolo[2,3-f]purine-2,4-diones were designed and synthesized as agents with potential biological activities.The final products were obtained by cyclization of carboxamide intermediates using 1,1,1,3,3,3,-hexamethyldisilazane.This procedure gave higher yields,and was more convenient and easier in purification compared to other methods.We also found polyphosphoric acid to be the most efficient agent in the cyclization of 8-[2-(p-(un)substituted-phenyl)-2-oxo-ethylsulfanyl]-1,3-dipropyl-3,7-dihydro-purine-2,6-diones to 1,3-dipropyl-6-substi-tuted)-1H-thiazolo[2,3-f]purine-2,4-diones.

机译：设计并合成了新的1,3,8-三取代嘌呤-2,6-二酮和1,3,6-三取代噻唑[2,3-f]嘌呤-2,4-二酮作为具有潜在生物活性的试剂最终产物是通过使用1,1,1,3,3,3，-六甲基二硅氮烷环化羧酰胺中间体而获得的。与其他方法相比，该方法收率更高，纯化更方便，更容易。酸是8- [2-（对-（未）取代的苯基）-2-氧代-乙基硫烷基] -1,3-二丙基-3,7-二氢嘌呤-2环化中最有效的试剂， 6-二酮对1,3-二丙基-6-取代的-1H-噻唑并[2,3-f]嘌呤-2,4-二酮。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2007年第0期|共14页
作者
Alaa M.Hayallah; Michael Famulok;
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1. SYNTHESIS OF NEW 1,3,8-TRISUBSTITUTED PURINE-2,6-DIONES AND 1,3,6-TRISUBSTITUTED THIAZOLO[2,3-f]PURINE-2,4-DIONES [J] . Alaa M.Hayallah, Michael Famulok Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2007,第0期

机译：合成新的1,3,8-三取代嘌呤-2,6-二酮和1,3,6-三取代的噻唑并[2,3-f] PURINE-2,4-二酮
2. SYNTHESIS OF SOME NOVEL 1,3,6-TRISUBSTITUTED-ltf-THIAZOLO[3,2./]PURINE-2,4-DIONES AND XANTHINE SCHIFF BASES AS POTENIAL ANTI-ASTHMATIC AND ANTI-INFLAMMATORY AGENTS [J] . Alaa M. Hayallah, Reham Abu Shmeis, Ahmad A. Talhouni Bulletin of pharmaceutical sciences . 2015,第1期

机译：一些新的1,3,6-三取代 - LTF-Thiazolo [3,2 ./]嘌呤-2,4-致力和黄嘌呤Schiff碱作为药水抗哮喘和抗炎剂
3. Solid-Phase Synthesis of 1,3,6-Trisubstituted-1H-thiazolo[4,5-c][1,2]thiazin-4(3H)one-2,2-dioxide Derivatives using Traceless Linker [J] . Taeho Lee, Ji-Hoon Park, Moon-Kook Jeon Journal of combinatorial chemistry . 2009,第2期

机译：使用无痕连接剂固相合成1,3,6-三取代-1H-噻唑并[4,5-c] [1,2]噻嗪-4（3H）one-2,2-二氧化物衍生物
4. Microwave synthesis of 2,3,5-trisubstituted-1,3-imidazolidin-4-ones bearing 1,3,4-oxadiazole moiety and preliminary evaluation of their antibacterial activity [C] . Zeid Hassan Abood, Hayder Raheem Ali, Hussein Ali Qabel International Conference on Applied Science and Technology . 2019

机译：微波合成2,3,5-三取代-1,3-咪唑烷-4-轴承1,3,4-氧代唑部分，对其抗菌活性的初步评估
5. Synthesis and pharmacological activity of 1,3,6-trisubstituted-4-oxo-1,4-dihydro-quinoline-2-carboxylic acid derivatives as selective ET(A) antagonists. [D] . Patel, Hardik J. 2009

机译：1,3,6-三取代-4-氧代-1,4-二氢喹啉-2-羧酸衍生物作为选择性ET（A）拮抗剂的合成及药理活性。
6. Arylethyne Bromoboration–Negishi Coupling Route to E- or Z-Aryl-Substituted Trisubstituted Alkenes of ≥98 IsomericPurity. New Horizon in the Highly Selective Synthesis of Trisubstituted Alkenes [O] . Chao Wang, Zhaoqing Xu, Tomas Tobrman, -1

机译：芳基乙基溴生物溴化途径与E-或Z-芳基取代的三取代烯烃≥98％异常百分之二的烯烃。在高度选择性合成三取代烯烃中的新地平线
7. Discovery, synthesis and biochemical profiling of purine-2,6-dione derivatives as inhibitors of the human poly(A)-selective ribonuclease Caf1 [O] . Jadhav Gopal P., Kaur Ishwinder, Maryati Maryati, 2015

机译：嘌呤-2,6-二酮衍生物作为人类聚（A）选择性核糖核酸酶Caf1抑制剂的发现，合成和生化分析。

SYNTHESIS OF NEW 1,3,8-TRISUBSTITUTED PURINE-2,6-DIONES AND 1,3,6-TRISUBSTITUTED THIAZOLO[2,3-f]PURINE-2,4-DIONES

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