SYNTHESIS OF 2,4,5-TRISUBSTITUTED THIAZOLES WITH A 5-(N,N-DIMETHYLAMINOMETHYL)SUBSTITUENT

Bernhard Stump; Philipp C.Kohler; W.Bernd Schweizer

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SYNTHESIS OF 2,4,5-TRISUBSTITUTED THIAZOLES WITH A 5-(N,N-DIMETHYLAMINOMETHYL)SUBSTITUENT

机译：用5-（N，N-二甲基亚氨基甲基）取代基合成2,4,5-三取代的噻唑

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We report synthetic strategies to 2,4,5-trisubstituted thiazoles with a N,N-dimethylaminomethyl residue at C(5).Three different routes to build up these scaffolds are described.Furthermore,we report a retro-Brook rearrangement of a thiazole derivative as well as an unusual cyclization leading to a highly substituted benzothiazole.

机译：我们报告合成策略的C，（5）具有N，N-二甲基氨基甲基残基的2,4,5-三取代噻唑。描述了建立这些支架的三种不同途径。此外，我们报道了噻唑的逆布鲁克重排衍生物以及异常环化导致高度取代的苯并噻唑。

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《Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry》 |2007年第0期|共34页
作者
Bernhard Stump; Philipp C.Kohler; W.Bernd Schweizer;
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1. SYNTHESIS OF 2,4,5-TRISUBSTITUTED THIAZOLES WITH A 5-(N,N-DIMETHYLAMINOMETHYL)SUBSTITUENT [J] . Bernhard Stump, Philipp C.Kohler, W.Bernd Schweizer Heterocycles: An International Journal for Reviews and Communications in Heterocyclic Chemistry . 2007,第0期

机译：用5-（N，N-二甲基亚氨基甲基）取代基合成2,4,5-三取代的噻唑
2. Synthesis and biological evaluation of 2,4,5-trisubstituted thiazoles as antituberculosis agents effective against drug-resistant tuberculosis [J] . Karale Uttam B., Krishna Vagolu Siva, Krishna E. Vamshi, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2019,第期

机译：2,4,5-三取代的噻唑作为抗尿性结核病有效抗尿嘧啶剂的合成及生物学评价
3. Design and Solid-Phase Parallel Synthesis of 2,4,5-Trisubstituted Thiazole Derivatives via Cyclization Reaction with a Carbamimidothioate Linker [J] . Kwon Hye-Jin, Kim Ye-Ji, Han Si-Yeon, ACS combinatorial science . 2019,第6期

机译：通过与氨基化反应与氨基甲酰基接头的环化反应设计和固相并行合成2,4,5-三取代的噻唑衍生物
4. Synthesis and Optical Properties of Dipolar Thiazole Derivatives Incorporating Nitro and Amino Substituents [C] . Noor Aisyah Ahmad Shah, Nur Farahin Pairan, Noor Azilah Mohd Kasim International Conference on Applied Engineering, Materials and Mechanics . 2018

机译：掺入硝基和氨基取代基的偶极噻唑衍生物的合成与光学性质
5. I. SYNTHESIS OF AN ANALOG OF HALITOXIN. II. STRUCTURE DETERMINATION OF IMIDAZOLE AND THIAZOLE METABOLITES FROM AN UNIDENTIFIED ASCIDIAN FROM SOUTH AUSTRALIA. III. SYNTHESIS OF (4-HYDROXY-3 - METHOXYBENZOYL)THIAZOLE, AND 2-((4-HYDROXY-3 - METHOXYPHENYL)HY [D] . ARABSHAHI, LILI. 1986

机译：一，类似毒素的合成。二。从澳大利亚南部未鉴定的阿西德人中咪唑和噻唑代谢物的结构测定。三，（4-羟基-3-甲氧基苯甲酰）噻唑和2-（（4-羟基-3-甲氧基苯）HY的合成
6. One-pot synthesis and in-vitro anticancer evaluation of 5-(2′-indolyl)thiazoles [O] . Buchi Reddy Vaddula, Mukund P. Tantak, Rachana Sadana, -1

机译：5-（2-吲哚基）噻唑的一锅合成和体外抗癌评价
7. SYNTHESIS AND MOLECULAR DOCKING OF 2,4,5-TRISUBSTITUTED-1,3-THIAZOLE DERIVATIVES AS ANTIBACTERIAL AGENTS [O] . 2019

机译：2,4,5-三取代-1,3-噻唑衍生物作为抗菌剂的合成与分子对接

SYNTHESIS OF 2,4,5-TRISUBSTITUTED THIAZOLES WITH A 5-(N,N-DIMETHYLAMINOMETHYL)SUBSTITUENT

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