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首页> 外文期刊>Japanese Journal of Ophthalmology >Plasma level of interleukin-6 is an indicator for predicting diabetic macular edema.
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Plasma level of interleukin-6 is an indicator for predicting diabetic macular edema.

机译：白细胞介素6的血浆水平是预测糖尿病性黄斑水肿的指标。

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PURPOSE: To find a predictor in the pathogenesis of macular edema, we investigated ocular and systemic risk factors. METHODS: One hundred and fifty-nine patients with mild diabetic retinopathy who showed one or more soft exudates were recruited. We selected the possible predictors on the basis of relevant factors, including concentration of vascular endothelial growth factor, interleukin-6 (IL-6), transforming growth factor (TGF)-beta(1), tumor necrosis factor (TNF)-alpha, and lipoprotein(a) in plasma, and serum level of von Willebrand factor and thrombomodulin. RESULTS: Macular edema was not detected in 94 eyes; focal macular edema was detected in 46 eyes; diffuse macular edema was detected in 18 eyes; and cystoid macular edema was present in 1 eye. The plasma level of IL-6 concentration and the state of the posterior vitreous detachment (PVD) correlated significantly with the severity of macular edema (odds ratios = 3.68, 1.70, respectively). Other risk factors were not significantly associated with macular edema. We estimated the probability of macular edema according to the IL-6 level in plasma and the state of the PVD, and were able to predict the probability of macular edema. CONCLUSION: The results of the present study indicate that IL-6 concentration in plasma and the state of the PVD can be predictors of macular edema.
机译：目的：为了找到黄斑水肿发病机理的预测指标，我们调查了眼部和全身性危险因素。方法：招募了159例表现出一种或多种软性渗出物的轻度糖尿病性视网膜病患者。我们根据相关因素选择了可能的预测因素，包括血管内皮生长因子，白介素-6（IL-6），转化生长因子（TGF）-β（1），肿瘤坏死因子（TNF）-α，血浆中的脂蛋白（a）以及血清von Willebrand因子和血栓调节蛋白的水平。结果：94只眼未检出黄斑水肿。在46只眼中发现了黄斑局灶性水肿;在18只眼中发现了黄斑弥漫性浮肿; 1只眼出现黄斑囊样水肿。血浆IL-6浓度水平和玻璃体后脱离（PVD）的状态与黄斑水肿的严重程度显着相关（比值分别为3.68、1.70）。其他危险因素与黄斑水肿无关。我们根据血浆中IL-6水平和PVD的状态估算了黄斑水肿的可能性，并能够预测黄斑水肿的可能性。结论：本研究结果表明血浆中IL-6浓度和PVD状态可以预测黄斑水肿。

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