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首页> 外文期刊>Japanese Journal of Ophthalmology >Retinoblastoma in Taiwan: survival and clinical characteristics 1978-2000.
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Retinoblastoma in Taiwan: survival and clinical characteristics 1978-2000.

机译：台湾视网膜母细胞瘤：生存期和临床特征1978-2000年。

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PURPOSE: Few estimates of the survival rates ofwas retinoblastoma have been reported from the Asia region. In this study, we aim to describe the survival and clinical characteristics of 96 retinoblastoma cases treated at Chang Gung Medical Center, Taipei, between 1978 and 2000.METHODS: We retrospectively analyzed the clinical records of 96 children (116 eyes) diagnosed with retinoblastoma and treated between 1978 and 2000. Information on sex, laterality, age at diagnosis, presenting signs, spread of tumor, treatment modality, survival rate, and family history were collected.RESULTS: Seventy-six (79.2%) cases were unilateral and 20 (20.8%) were bilateral. The mean age overall at the time of diagnosis was 24.7 months; in unilateral cases, 27.1 months; and in bilateral cases, 15.6 months. The most common presenting signs were leukocoria (75 cases, 78.1.0%), buphthalmos (34 cases, 35.4%), proptosis (16 cases, 16.7%), and strabismus (12 cases, 12.5%). Forty-two eyes had orbital extension, 27 patients had central nervous system invasion, 16 cases exhibited bone marrow involvement, and 3 cases had liver metastasis. Three (3.1%) patients had a family history of retinoblastoma. None of the cases developed a secondary neoplasm. The 3-year cumulative survival rate of the 96 patients was 64.41% (unilateral, 71.97%; bilateral 40.01%).CONCLUSIONS: The mortality was much higher than that in reports on Western and Japanese patients. Delayed diagnosis with frequent extraocular spread at the time of diagnosis caused the low survival rate. Fewer familial cases were encountered in our study than in other studies.
机译：目的：在亚洲地区几乎没有关于视网膜母细胞瘤生存率的报道。在这项研究中，我们旨在描述1978年至2000年在台北长庚医学中心治疗的96例视网膜母细胞瘤患者的生存和临床特征。方法：我们回顾性分析了96例诊断为视网膜母细胞瘤的儿童（116眼）的临床记录。收治于1978年至2000年之间。收集了有关性别，偏侧，诊断时的年龄，体征，肿瘤扩散，治疗方式，存活率和家族史的信息。结果：单侧76例（79.2％），其中20例（79.2％）。 20.8％）是双边的。诊断时的总体平均年龄为24.7个月;在单方面情况下，为27.1个月;在双边病例中为15.6个月。最常见的体征是白细胞增多症（75例，78.1.0％），眼睑炎（34例，35.4％），眼球突出（16例，16.7％）和斜视（12例，12.5％）。眼眶扩张42眼，中枢神经系统侵犯27例，骨髓受累16例，肝转移3例。三名（3.1％）患者有视网膜母细胞瘤家族史。没有一个病例发生继发性肿瘤。 96例患者的3年累计生存率为64.41％（单侧为71.97％;双侧为40.01％）。结论：死亡率远高于西方和日本患者的报告。诊断时诊断频繁，眼外扩散，导致存活率低。与其他研究相比，我们的研究中遇到的家族病例更少。

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