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首页> 外文期刊>Japanese Journal of Ophthalmology >Ultrastructural changes in rat eyes with experimental Vogt-Koyanagi-Harada disease
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Ultrastructural changes in rat eyes with experimental Vogt-Koyanagi-Harada disease

机译：实验性Vogt-Koyanagi-Harada病大鼠眼睛的超微结构变化

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Purpose: To determine whether the ultrastructural changes in the eyes of an animal model of Vogt Koyanagi-Harada (VKH) disease are similar to those in human eyes with VKH disease.Methods: Pigmented rats derived by crossing brown Norway and Lewis rats were immunized with tyrosinase-family proteins, and the eyes were enucleated after different postinoculation times. The eyes were fixed in glutaraldehyde or formaldehyde and prepared for light or electron microscopy (EM).Results: EM showed that thickening of the choroid resulted from the invasion of many lymphocytes and epithelioid-like cells. The melanocytes were surrounded by lymphocytes and lost their normal spindle shape. Neutrophils and eosinophils were also present in the choroid. These findings are very similar to the changes reported in eyes from patients with VKH disease or sympathetic ophthalmia.Conclusions: The similarity of the ultrastructural changes in this model to those in human VKH disease indicate that this animal model can serve as a histopathological model of human VKH disease. (C) Japanese Ophthalmological Society 2004.
机译：目的：确定Vogt Koyanagi-Harada（VKH）疾病动物模型的眼睛的超微结构变化是否与患有VKH疾病的人眼睛的相似。酪氨酸酶家族蛋白，接种不同时间后摘除眼睛。眼睛固定在戊二醛或甲醛中，并准备进行光镜或电子显微镜（EM）检查。结果：EM显示脉络膜增厚是许多淋巴细胞和上皮样细胞浸润的结果。黑色素细胞被淋巴细胞包围，失去正常的纺锤形。脉络膜中也存在嗜中性粒细胞和嗜酸性粒细胞。这些发现与VKH疾病或交感性眼病患者的眼睛中的变化非常相似。结论：该模型的超微结构变化与人类VKH疾病的相似性表明，该动物模型可作为人类的组织病理学模型VKH病。 （C）日本眼科学会2004。

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