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首页> 外文期刊>Japanese Journal of Ophthalmology >Retinal vasculitis caused by adult T-cell leukemia/lymphoma
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Retinal vasculitis caused by adult T-cell leukemia/lymphoma

机译：成人T细胞白血病/淋巴瘤引起的视网膜血管炎

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Background: To report a case of lymphomatous infiltration and bilateral retinal vasculitis observed among 83 cases of adult T-cell leukemia (ATL) treated in the University Hospital Center in Fort-de-France (Martinique, French West Indies) between 1984 and 2003.Case: A complete clinical ophthalmologic examination was performed in this patient along with fluorescein angiography.Observations: After being checked for diffuse adenopathies, myodesopsias, and phosphenes, the 35-year-old patient was diagnosed with ATL. The ocular impairment, present since the onset of ATL as peripheral subretinal infiltrates, spread progressively and afferently to the rest of the retina in the form of an essentially venous vasculitis. Impairment of the vitreous was noted only in the end stages of disease progression. As ocular lesions progressed, the general state of the patient degraded at the same time despite chemotherapeutic measures.Conclusion: Among the more than 300 seropositive for human T-cell lymphotropic virus type 1 (HTLV-1) or patients with HTLV-1-associated myelopathy/tropical spastic paraparesis treated at our hospital in the last 20 years, and among the 83 cases of ATL, only this single case of retinal vasculitis associated with HTLV-1 was observed (1/83, 1.2%) in Martinique, confirming the geographic variability of the clinical phenotype of HTLV-1 infection. The incidence of retinal vasculitis in ATL patients may signify an even worse prognosis than initially indicated. (C) Japanese Ophthalmological Society 2005.
机译：背景：1984年至2003年在法兰西堡大学医院中心（法属西印度群岛马提尼克）治疗的83例成人T细胞白血病（ATL）患者中观察到一例淋巴瘤浸润和双侧视网膜血管炎。病例：对该患者进行了全面的临床眼科检查，同时进行了荧光素血管造影。观察：在检查了弥漫性腺病，肌弱视和磷化之后，该35岁患者被诊断出患有ATL。自从ATL发作以来就存在的眼损伤是周围性视网膜下浸润，以基本静脉血管炎的形式逐渐地和传入地传播到视网膜的其余部分。仅在疾病进展的末期才注意到玻璃体损伤。随着眼部病变的进展，尽管采取了化学治疗措施，但患者的总体状况却同时下降。结论：在300例人类T细胞淋巴病毒1型（HTLV-1）或HTLV-1相关患者血清阳性中在过去的20年中，我们医院治疗了脊髓病/热带痉挛性轻瘫，在83例ATL患者中，在马提尼克岛仅观察到与HTLV-1相关的视网膜血管炎这一病例（1/83，1.2％），证实了HTLV-1感染临床表型的地理变异性。在ATL患者中视网膜血管炎的发生可能表明预后比最初指示的还要差。 （C）日本眼科学会2005。

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