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首页> 外文期刊>Japanese Journal of Ophthalmology >Differential expression of mRNA for alpha 2,3-sialyltransferase during development of rat retina.
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Differential expression of mRNA for alpha 2,3-sialyltransferase during development of rat retina.

机译：大鼠视网膜发育过程中α2,3-唾液酸转移酶的mRNA差异表达。

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摘要

Glycoconjugates, consisting of O- and N-linked types, are present on the surface of photoreceptor cells and in the interphotoreceptor matrix (IPM). This study was undertaken to facilitate understanding of the metabolic features of O-linked sialoglycoconjugates in comparison with those of N-linked glycoconjugates in the rat retina. We examined the developmental change in distribution of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase mRNA in rat retinas using in situ hybridization histochemistry to detect the synthesis period of O-linked sialoglycans. Positive hybridization signal was observed in the ganglion cells throughout the postnatal days (P) examined, whereas strong signals were detected in the photoreceptor inner segments and the inner nuclear layer exclusively at P16 and P18. At P20 and older, weak or sparse signals were detected in these regions. It is likely that O-linked sialoglycoconjugates, which are detected in the mature IPM, are actively synthesized from P16 to P18 in the rat photoreceptor inner segments, suggesting that the O-linked sialoglycoconjugates in the photoreceptor layer may be stable with litter turnover in the mature retina.
机译：由O型和N型连接的糖共轭物存在于感光细胞表面和感光细胞间基质（IPM）中。进行该研究以促进与大鼠视网膜中N-连接的糖缀合物与N-连接的糖缀合物的代谢特征相比的理解。我们使用原位杂交组织化学方法检测O-连接唾液聚糖的合成时期，研究了大鼠视网膜中Gal beta 1,3GalNAc alpha 2,3-唾液酸转移酶mRNA分布的发育变化。在整个产后检查日（P），在神经节细胞中观察到阳性杂交信号，而仅在P16和P18的感光细胞内部节段和内部核层中检测到强信号。在P20及更高版本上，在这些区域中检测到微弱或稀疏的信号。在成熟的IPM中检测到的O联唾液酸共轭物很可能是在大鼠感光器内部节段中从P16到P18主动合成的，这表明光感受器层中的O联唾液酸共轭物可能是稳定的，并且产仔率更高。成熟的视网膜。

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