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A case of chronic recurrent uveitis associated with chronic granulomatous disease.

机译:一例与慢性肉芽肿病相关的慢性葡萄膜炎。

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摘要

Rare inherited chronic granulomatous disease (CGD) often causes life-threatening infections. Childhood CGD involves successive chronic granulomatous and suppurative lesions of multiple organs caused by the failure of leukocytes to kill certain microorganisms. This typically involves neutrophil dysfunction owing to impaired H_2O_2 production. CGD patients often suffer recurrent infections by catalase-positive and non-H_2O_2-producing microorganisms, including Staphylococcus,Pseudomonas, and Salmonella, generally resulting from pneumonia, suppurative adenitis, or subcutaneous abscess. The major known ocular manifestations are blepharoconjunctivitis and chorioretinal scars. Here we describe a CGD patient with chronic recurrent uveitis.
机译:罕见的遗传性慢性肉芽肿性疾病(CGD)通常导致威胁生命的感染。儿童期CGD涉及由白细胞杀死某些微生物的失败引起的多个器官的连续慢性肉芽肿和化脓性病变。由于H_2O_2生成受损,这通常涉及中性粒细胞功能障碍。 CGD患者经常遭受过氧化氢酶阳性和不产生H_2O_2的微生物(包括葡萄球菌,假单胞菌和沙门氏菌)的反复感染,这些微生物通常是由肺炎,化脓性腺炎或皮下脓肿引起的。已知的主要眼部表现是睑结膜炎和脉络膜视网膜瘢痕。在这里,我们描述了患有慢性复发性葡萄膜炎的CGD患者。

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