...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Japanese Journal of Ophthalmology >Clinical efficacy of topical nipradilol and timolol on visual field performance in normal-tension glaucoma: a multicenter, randomized, double-masked comparative study.
【24h】

Clinical efficacy of topical nipradilol and timolol on visual field performance in normal-tension glaucoma: a multicenter, randomized, double-masked comparative study.

机译：局部尼普地洛和噻吗洛尔对正常血压青光眼视野性能的临床疗效：一项多中心，随机，双掩盖比较研究。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: To compare the effects of topical nipradilol and timolol on the visual field in Japanese normaltension glaucoma (NTG) patients. METHODS: We enrolled 146 NTG patients. At baseline, age, intraocular pressure (IOP), and mean deviation (MD) by the Humphrey field analyzer were 47.6 (SD 8.5), 14.2 (1.7) mmHg, and -4.5 (3.0) dB. Seventy-two patients were randomly assigned to the 0.25% nipradilol group and 74 patients to the 0.5% timolol ophthalmic solution group twice daily for the 3-year study period. The Humphrey full-threshold 30-2 visual field test was performed every 6 months. The primary end point was the nonparametric O'Brien summary score (sum of the ranks of six slopes calculated from the average of the total deviation in each cluster) in each patient. The secondary analyses were differences in the MD slope, average of the total deviation in each cluster, the corrected pattern standard deviation (CPSD), and the time course of IOP. RESULTS: No significant intergroup differences were found in baseline characteristics, or in the parameters of the primary and secondary analyses. In both groups, central superior clusters showed negative slopes and IOP decreased by about 1 mmHg from baseline. CONCLUSION: No significant difference in visual field performance or IOP reduction was seen between the nipradilol and timolol groups.
机译：目的：比较日本正常血压青光眼（NTG）患者局部使用奈地洛尔和噻吗洛尔对视野的影响。方法：我们招募了146例NTG患者。在基线时，汉弗莱场分析仪的年龄，眼压（IOP）和平均偏差（MD）为47.6（SD 8.5），14.2（1.7）mmHg和-4.5（3.0）dB。在为期3年的研究期间，每天两次两次将72例患者随机分配至0.25％尼地洛尔组，将74例患者随机分配至0.5％替莫洛尔滴眼液组。每6个月进行一次汉弗莱全阈值30-2视野测试。主要终点是每位患者的非参数O'Brien总评分（根据每个组中总偏差的平均值计算出的六个斜率等级的总和）。次要分析是MD斜率，每个群集中总偏差的平均值，校正模式标准偏差（CPSD）和IOP时程的差异。结果：基线特征或主要和次要分析的参数均未发现明显的组间差异。在两组中，中央上等群集均显示负斜率，并且眼压从基线下降约1 mmHg。结论：尼普地洛和噻吗洛尔组在视野性能或眼压降低方面无显着差异。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号