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首页> 外文期刊>Circulation journal >Pravastatin decreases blood pressure in hypertensive and hypercholesterolemic patients receiving antihypertensive treatment.
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Pravastatin decreases blood pressure in hypertensive and hypercholesterolemic patients receiving antihypertensive treatment.

机译：普伐他汀可降低接受降压治疗的高血压和高胆固醇血症患者的血压。

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BACKGROUND: Previous studies have suggested that the lipid-lowering agents, statins, may help reduce blood pressure (BP). The goal of the present study was to characterize the effect of pravastatin on BP in hypercholesterolemic and hypertensive patients already receiving antihypertensive drugs. METHODS AND RESULTS: Eighty-two patients with hypercholesterolemia were retrospectively studied before and after 3 months of treatment with pravastatin. Forty-four patients had hypertension (HT group) and were receiving antihypertensive treatment, while the remaining 38 patients were normotensive (NT group). Patients in the HT group were further subdivided into those with uncontrolled or controlled BP. Pravastatin treatment significantly reduced systolic BP (SBP) in the HT group (134+/-16 to 130+/-13 mmHg, p<0.005) but not in the NT group (124+/-10 to 123+/-9 mmHg, p=0.52), despite the fact that treatment significantly reduced low-density lipoprotein cholesterol in both groups (HT group 178+/-27 to 132+/-17 mg/dl, p<0.0001; NT group 169+/-27 to 125+/-21 mg/dl, p<0.0001). Further, pravastatin significantly decreased SBP in the uncontrolled BP group (148+/-7 to 138+/-12 mmHg, p<0.005) but not in the controlled BP group (122+/-10 to 123+/-9 mmHg, p=0.72). CONCLUSION: Concomitant use of statins and antihypertensive drugs could result in improved BP control in hypertensive patients with hypercholesterolemia.
机译：背景：先前的研究表明，降脂药他汀类药物可能有助于降低血压（BP）。本研究的目的是表征普伐他汀对已经接受降压药治疗的高胆固醇血症和高血压患者的血压影响。方法与结果：回顾性研究了普伐他汀治疗3个月前后的82例高胆固醇血症患者。四十四名患有高血压的患者（HT组）正在接受降压治疗，而其余三十八名患者为血压正常的患者（NT组）。 HT组的患者被进一步分为血压不受控制或受控制的患者。普伐他汀治疗可显着降低HT组的收缩压（SBP）（134 +/- 16至130 +/- 13 mmHg，p <0.005），而NT组则无此作用（124 +/- 10至123 +/- 9 mmHg） ，p = 0.52），尽管两组治疗均显着降低了低密度脂蛋白胆固醇水平（HT组178 +/- 27至132 +/- 17 mg / dl，p <0.0001; NT组169 +/- 27至125 +/- 21 mg / dl，p <0.0001）。此外，普伐他汀在不受控制的BP组（148 +/- 7至138 +/- 12 mmHg，p <0.005）显着降低SBP，但在不受控制的BP组（122 +/- 10至123 +/- 9 mmHg， p = 0.72）。结论：他汀类药物和降压药的同时使用可改善高血压高胆固醇血症患者的血压控制。

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