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首页> 外文期刊>Circulation journal >Comparison of efficacy of sotalol and nifekalant for ventricular tachyarrhythmias.
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Comparison of efficacy of sotalol and nifekalant for ventricular tachyarrhythmias.

机译：索他洛尔和硝苯卡那特治疗室速性心律失常的疗效比较。

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BACKGROUND: Suppression of implantable defibrillator discharges associated with ventricular tachyarrhythmia (VTA) has been reported for sotalol. This study aimed to investigate the efficacy of intravenous nifekalant hydrochloride in predicting the effects of oral sotalol. METHODS AND RESULTS: The present study included 14 patients who had sustained VTA associated with structural heart disease. All patients also had inducible VTA. To compare the effects of nifekalant and sotalol, programmed electrical stimulation was performed, in the basal state, after nifekalant administration, and after sotalol administration. Nifekalant and sotalol similarly prolonged the corrected QT interval and ventricular effective refractory periods, but the heart rate was slowed by sotalol only. In 4 of 5 patients whose VTA became non-inducible by nifekalant, subsequent treatment with sotalol also suppressed the inducible VTA. In all of the 9 patients non-responding to nifekalant, VTA remained inducible during sotalol treatment. Nifekalant accurately predicted the response to sotalol during electrophysiologic study in 13 of 14 patients. Of 11 patients who remained on sotalol, VTA recurred in 3 non-responders during a follow-up of 46 +/- 11 months. CONCLUSIONS: Nifekalant and sotalol had similar effects on inducible VTA. The response of inducible VTA to nifekalant may predict the clinical efficacy of sotalol.
机译：背景：据报道，索他洛尔抑制了与室速性心律失常（VTA）相关的植入式除颤器放电。这项研究旨在探讨静脉注射硝苯卡坦盐酸盐在预测口服索他洛尔疗效方面的功效。方法和结果：本研究包括14例持续性VTA伴结构性心脏病的患者。所有患者还具有诱导型VTA。为了比较硝苯卡兰和索他洛尔的作用，在硝苯卡兰剂给药后和索他洛尔给药后，在基础状态下进行了程序电刺激。 Nifekalant和索他洛尔同样延长了校正的QT间隔和心室有效不应期，但仅索他洛尔使心律减慢。在5例患者中，其中有4例因硝苯丙胺无法诱导VTA，随后的索他洛尔治疗也抑制了诱导性VTA。在对奈非卡兰无反应的所有9位患者中，索他洛尔治疗期间VTA仍可诱导。 Nifekalant在14位患者中有13位在电生理研究中准确预测了对索他洛尔的反应。在11例仍使用索他洛尔的患者中，在46 +/- 11个月的随访期间，有3例无反应者复发了VTA。结论：硝苯卡那特和索他洛尔对诱导型VTA的作用相似。诱导性VTA对硝苯丙酸的反应可预测索他洛尔的临床疗效。

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