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首页> 外文期刊>Circulation journal >Angiotensin II Receptor Blocker Prevents Increased Arterial Stiffness in Patients With Essential Hypertension.
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Angiotensin II Receptor Blocker Prevents Increased Arterial Stiffness in Patients With Essential Hypertension.

机译：血管紧张素II受体阻滞剂可防止原发性高血压患者的动脉僵硬度增加。

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Background High pulse wave velocity (PWV) is related to cardiovascular risk in essential hypertension (EHT). It is reported that short-term treatment with an angiotensin II receptor blocker (ARB) decreases PWV, as well as blood pressure (BP), and increases the serum adiponectin, known as an adipocytokine, which has an anti-atherosclerotic effect. However, it is not known whether long-term treatment with ARB prevents the increase in PWV independently of the reduction of BP, and whether adiponectin is related to the chronic effect of ARB on PWV. Methods and Results In order to examine the short-term effect of ARB on PWV, 9 subjects with EHT had PWV measured before and after treatment with an ARB for 1 month. The treatment significantly reduced PWV and BP. For evaluation of the long-term effect of ARB therapy, 56 consecutive subjects with EHT who were already taking anti-hypertensive drugs other than an angiotensin-converting enzyme inhibitor had their PWV measured. We divided the EHT subjects into 2 groups: (1) the ARB group (EHT treated with an ARB for at least 6 months) and (2) the control group (EHT treated with anti-hypertensive drugs other than an ARB). Although there was no significant difference between the 2 groups in BP, age or body mass index, the PWV value in the ARB group was significantly lower than that in the control group. Moreover, the serum adiponectin concentration in the ARB group was significantly higher than that in the control group. Conclusions Long-term treatment with ARB inhibits the progression of arterial stiffness independent of BP reduction. One of the mechanisms may be related to the increased serum adiponectin concentration after treatment with an ARB. (Circ J 2004; 68: 1194 - 1198).
机译：背景高脉搏波速度（PWV）与原发性高血压（EHT）的心血管风险有关。据报道，用血管紧张素II受体阻滞剂（ARB）进行短期治疗可降低PWV和血压（BP），并增加血清脂联素（称为脂细胞因子），具有抗动脉粥样硬化作用。然而，不知道ARB的长期治疗是否能独立于BP的降低而阻止PWV的增加，以及脂联素是否与ARB对PWV的慢性作用有关。方法和结果为了检查ARB对PWV的短期影响，对9名EHT受试者在ARB治疗1个月前后进行了PWV测量。治疗显着降低了PWV和BP。为了评估ARB治疗的长期效果，已经连续56名已经服用了除血管紧张素转换酶抑制剂以外的降压药的EHT患者的PWV进行了测量。我们将EHT受试者分为两组：（1）ARB组（用ARB治疗至少6个月的EHT）和（2）对照组（用除ARB以外的抗高血压药物治疗的EHT）。尽管两组之间的血压，年龄或体重指数无显着差异，但ARB组的PWV值明显低于对照组。此外，ARB组的血清脂联素浓度显着高于对照组。结论长期应用ARB可以抑制动脉僵硬度的进展，而与BP降低无关。机制之一可能与ARB治疗后血清脂联素浓度升高有关。 （Circ J 2004; 68：1194-1198）。

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