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首页> 外文期刊>Circulation journal >Elevated plasma osteopontin levels were associated with osteopontin expression of CD4+ T cells in patients with unstable angina.
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Elevated plasma osteopontin levels were associated with osteopontin expression of CD4+ T cells in patients with unstable angina.

机译：不稳定型心绞痛患者血浆骨桥蛋白水平升高与CD4 + T细胞骨桥蛋白表达相关。

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BACKGROUND: Plaque instability in patients with unstable angina (UA) is associated with stimulated CD4+ T cells, so the present study investigated whether there is a relationship among plaque instability, osteopontin and CD4+ T cells. METHODS AND RESULTS: Peripheral blood mononuclear cells were collected from 51 consecutive patients with UA, 60 patients with stable angina (SA), and 39 patients with chest pain syndrome (CPS). Osteopontin-producing CD4+ T cells were quantified by flow cytometry. Plasma osteopontin levels (ng/ml) were measured by ELISA and were higher in patients with UA (792.0 +/- 316.7) than in those with SA (626.0 +/- 195.0, p < 0.005) or CPS (594.7 +/- 239.4, p < 0.005). The frequency (%) of osteopontin-producing CD4+ T cells was higher in patients with UA (26.7 +/- 13.3) than in those with SA (19.5 +/- 11.1, p < 0.05) or CPS (16.6 +/- 9.0, p < 0.005). Furthermore, the plasma osteopontin level correlated with the frequency of osteopontin-producing CD4+ T cells (r = 0.327, p = 0.0004),as did the high-sensitivity C-reactive protein level (r = 0.360, p = 0.0002). CONCLUSIONS: The plasma osteopontin levels are elevated in patients with UA, accompanied by an increase in the number of osteopontin-production of circulating CD4+ T cells. Circulating CD4+ T cells may play a role through osteopontin in the pathophysiology of UA.
机译：背景：不稳定型心绞痛（UA）患者的斑块不稳定性与刺激的CD4 + T细胞有关，因此，本研究调查了斑块不稳定性，骨桥蛋白和CD4 + T细胞之间是否存在关系。方法与结果：收集51例连续UA患者，60例稳定型心绞痛（SA）患者和39例胸痛综合征（CPS）患者的外周血单个核细胞。通过流式细胞术定量产生骨桥蛋白的CD4 + T细胞。通过ELISA测定的血浆骨桥蛋白水平（ng / ml），UA患者（792.0 +/- 316.7）高于SA患者（626.0 +/- 195.0，p <0.005）或CPS（594.7 +/- 239.4） ，p ＜0.005）。 UA（26.7 +/- 13.3）患者中产生骨桥蛋白的CD4 + T细胞的频率（％）高于SA（19.5 +/- 11.1，p <0.05）或CPS（16.6 +/- 9.0， p <0.005）。此外，血浆骨桥蛋白水平与产生骨桥蛋白的CD4 + T细胞的频率相关（r = 0.327，p = 0.0004），以及高敏感性C反应蛋白水平（r = 0.360，p = 0.0002）。结论：UA患者血浆骨桥蛋白水平升高，同时循环CD4 + T细胞的骨桥蛋白产生数量增加。循环中的CD4 + T细胞可能通过骨桥蛋白在UA的病理生理中发挥作用。

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