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首页> 外文期刊>Circulation journal >Acute effects of diltiazem on regional left ventricular diastolic filling dynamics in patients with hypertrophic cardiomyopathy as assessed by color kinesis.
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Acute effects of diltiazem on regional left ventricular diastolic filling dynamics in patients with hypertrophic cardiomyopathy as assessed by color kinesis.

机译：如通过彩色运动学评估，地尔硫卓对肥厚型心肌病患者局部左心室舒张期充盈动态的急性影响。

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摘要

BACKGROUND: The effect of calcium antagonists on regional left ventricular (LV) filling dynamics in patients with hypertrophic cardiomyopathy (HCM) is not well known, so the present study evaluated the results of echocardiography with color kinesis (CK) analysis during diltiazem infusion. METHODS AND RESULTS: Nineteen patients (16 men, 3 women; mean age 55+/-15 years) underwent echocardiography with CK analysis during intravenous diltiazem (10 mg/2 min). Using the quantitative CK software the LV short-axis image was divided into 6 segments and the percent endocardial expansion at the early, mid- and late-diastolic filling time was averaged for all segments, with the standard deviation of the mean used as an index of diastolic asynchrony (asynchrony index). The regional mean filling time was also measured for the corresponding segments. As global diastolic parameters, the global filling time, peak filling rate, and the time-to-peak filling were calculated. After the administration of diltiazem, the asynchrony index was decreased for all three diastolic filling times. Diltiazem shortened the mean filling time overall, especially in the posterior and lateral wall segments. These findings were associated with significant improvement in the CK-derived global diastolic parameters. CONCLUSIONS: Diltiazam has a favorable effect on LV diastolic asynchrony, which may account for the acute changes in global LV relaxation.
机译：背景：钙拮抗剂对肥厚型心肌病（HCM）患者局部左心室（LV）充盈动态的影响尚不清楚，因此本研究评估了地尔硫卓输注期间超声心动图与彩色运动学（CK）分析的结果。方法和结果：19例患者（男16例，女3例;平均年龄55 +/- 15岁）在静脉地尔硫卓（10 mg / 2分钟）期间接受了CK分析的超声心动图检查。使用定量CK软件，将LV短轴图像分为6个部分，并在所有舒张期的舒张早期，中期和晚期充盈时间平均心内膜扩张百分比，并以平均值的标准偏差作为指标舒张期异步性（异步索引）。还测量了相应段的区域平均填充时间。作为全局舒张压参数，计算了全局填充时间，峰值填充速率和达到峰值的时间。地尔硫卓给药后，所有三个舒张期充盈时间的异步指数均降低。地尔硫卓缩短了总体平均充血时间，尤其是在后壁和侧壁段。这些发现与CK衍生的整体舒张参数的显着改善有关。结论：地尔硫卓对左室舒张期异步性有良好的影响，这可能解释了整体性左室舒张的急性变化。

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