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首页> 外文期刊>Circulation journal >Impact of Metabolic Syndrome on 10-Year Clinical Outcomes Among Patients With Acute Coronary Syndrome
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Impact of Metabolic Syndrome on 10-Year Clinical Outcomes Among Patients With Acute Coronary Syndrome

机译：代谢综合征对急性冠脉综合征患者10年临床结果的影响

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Background: Metabolic syndrome (MetS) is a risk factor and prognosticator for ischemic heart disease, but its actual effect on long-term mortality after acute coronary syndrome (ACS) remains unknown. Methods and Results: All-cause death and cardiovascular death were investigated among patients with ACS upon admission who underwent complete revascularization by either percutaneous coronary intervention or bypass surgery between 1984 and 1992. MetS was denned according to the NCEP/ATPIII criteria modified for waist circumference. From among 1,836 patients who underwent complete revascularization during the study period, 384 (21.0%) with ACS were enrolled, of whom 163 (42.5%) had MetS. During a mean follow-up of 10.4?4 years, the total number of deaths was 83 (21.6%), of which 38 (9.9%) were from cardiovascular causes. Cox proportional hazard analysis revealed that MetS increased the risk of mortality by a ratio of 1.62 (95% confidence interval (CI) 1.01-2.59, P=0.046) and of cardiovascular death by 2.40 (95%CI 1.16-4.94, P=0.018) in patients with ACS.Conclusions: MetS is a powerful determinant of long-term all-cause and cardiovascular death after ACS. Furthermore, MetS and ACS might jointly exacerbate poor long-term outcomes.
机译：背景：代谢综合征（MetS）是缺血性心脏病的危险因素和预后指标，但其对急性冠脉综合征（ACS）长期死亡率的实际影响尚不清楚。方法和结果：对1984年至1992年间通过经皮冠状动脉介入治疗或旁路手术进行了完全血运重建的ACS患者的全因死亡和心血管死亡进行了调查。根据针对腰围的NCEP / ATPIII标准对MetS进行了定义。在研究期间的1836例接受了完全血运重建的患者中，384例（21.0％）患有ACS，其中163例（42.5％）患有MetS。在平均10.4至4年的随访中，死亡总数为83（21.6％），其中38（9.9％）是心血管原因。 Cox比例风险分析显示，MetS使死亡风险增加了1.62（95％置信区间（CI）1.01-2.59，P = 0.046），心血管死亡增加了2.40（95％CI 1.16-4.94，P = 0.018）结论：MetS是ACS后长期全因和心血管死亡的有力决定因素。此外，MetS和ACS可能共同加剧不良的长期结果。

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