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首页> 外文期刊>Circulation journal >Elevated Arterial Stiffness Evaluated by Brachial-Ankle Pulse Wave Velocity is Deleterious for the Prognosis of Patients With Heart Failure
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Elevated Arterial Stiffness Evaluated by Brachial-Ankle Pulse Wave Velocity is Deleterious for the Prognosis of Patients With Heart Failure

机译：臂踝脉搏波速度评估动脉僵硬度对心力衰竭患者的预后有害

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Background: Arterial stiffness is used as an index of arteriosclerosis. The goal of this study was to clarify whether increased arterial stiffness, evaluated by measuring the brachial-ankle pulse wave velocity (baPWV), is a risk factor for the prognosis of heart failure (HF) patients.Methods and Results: After examination of the baPWV, as well as the levels of neurohumoral factors, the 72 enrolled HF patients were followed up for a survival study, which had a primary endpoint of re-admission because of HF. The secondary endpoint was cardiac death. Results of Cox proportional hazards modeling revealed that baPWV, systolic blood pressure (BP) and brain natriuretic peptide level were factors that affected survival (P<0.05). The patients were divided into 2 groups according to the cutoff baPWV value (l,750cm/s). Although hemodynamic factors were similar between the groups, the high-baPWV group had a lower event-free survival rate for the primary and secondary endpoints than the low-baPWV group (P<0.05). BP at re-admission was higher in the high-baPWV group (174+-30 mmHg) than in the low-baPWV group (121+-33 mmHg, P<0.01).
机译：背景：动脉僵硬度被用作动脉硬化的指标。这项研究的目的是弄清通过测量臂踝脉搏波速度（baPWV）评估的动脉僵硬是否是心力衰竭（HF）患者预后的危险因素。对baPWV以及神经体液因素的水平，对72名入选的HF患者进行了随访，以进行生存研究，该研究的主要终点是因为HF。次要终点是心脏死亡。 Cox比例风险建模结果表明，baPWV，收缩压（BP）和脑钠肽水平是影响生存率的因素（P <0.05）。根据临界baPWV值（1,750cm / s）将患者分为两组。尽管两组之间的血流动力学因素相似，但高baPWV组的主要终点和次要终点的无事件生存率低于低baPWV组（P <0.05）。高baPWV组（174 + -30 mmHg）的再入院血压高于低baPWV组（121 + -33 mmHg，P <0.01）。

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