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Approximation algorithms for constrained generalized tree alignment problem

机译:约束广义树对齐问题的近似算法

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In generalized tree alignment problem, we are given a set S of k biologically related sequences and we are interested in a minimum cost evolutionary tree for S. In many instances of this problem partial phylogenetic tree for S is known. In such instances, we would like to make use of this knowledge to restrict the tree topologies that we consider and construct a biologically relevant minimum cost evolutionary tree. So, we propose the following natural generalization of the generalized tree alignment problem, a problem known to be MAX-SNP Hard, stated as follows: Constrained Generalized Tree Alignment Problem [S. Divakaran, Algorithms and heuristics for constrained generalized alignment problem, DIMACS Technical Report 2007-21, 2007]: Given a set S of k related sequences and a phylogenetic forest comprising of node-disjoint phylogenetic trees that specify the topological constraints that an evolutionary tree of S needs to satisfy, construct a minimum cost evolutionary tree for S. In this paper, we present constant approximation algorithms for the constrained generalized tree alignment problem. For the generalized tree alignment problem, a special case of this problem, our algorithms provide a guaranteed error bound of 2 - 2/k.
机译:在广义树对齐问题中,我们给定了一个由k个生物学相关序列组成的集合S,并且我们对S的最小成本进化树感兴趣。在此问题的许多情况下,S的部分系统树是已知的。在这种情况下,我们想利用这些知识来限制我们考虑的树形拓扑结构,并构建生物学上相关的最小成本进化树。因此,我们提出了广义树对齐问题的以下自然归纳,即称为MAX-SNP Hard的问题,表述如下:约束广义树对齐问题[S. Divakaran,受约束的广义比对问题的算法和启发式方法,DIMACS技术报告2007-21,2007]:给定一组S个k相关序列,以及一个由节点不相交的系统树组成的系统树,这些树指定了拓扑约束,即S需要满足,为S构造一个最小代价的进化树。在本文中,我们提出了约束广义树对齐问题的常数逼近算法。对于广义树对齐问题(该问题的特殊情况),我们的算法提供了2-2 / k的有保证的误差范围。

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