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首页> 外文期刊>Circulation journal >Is measuring oxidative stress useful in predicting organ-damage in respect of cardio-renal relations?
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Is measuring oxidative stress useful in predicting organ-damage in respect of cardio-renal relations?

机译:测量氧化应激是否有助于预测心肾关系方面的器官损伤?

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摘要

It is well recognized that chronic and acute renal dysfunction are important factors determining prognosis of patients, and also the upcoming issue of health care costs. Therefore, markers to detect early-stage renal dysfunction and also that can predict mortality in renal failure patients has been a research interest for a long time. Urine casts, urinary albumin/protein levels and the glomerular filtration rate have been used clinically for a long time and adding to these classical markers, cystatin C, and pentosi-dine are approved markers to diagnose glomerular or tubular dysfunction in Japan. However, the limitations of these conventional markers for early detection and accurate estimation of renal injury are well known. Moreover, their predictive value of cardiovascular events and mortality is limited. So, novel renal biomarkers are indispensable.
机译:众所周知,慢性和急性肾功能不全是决定患者预后的重要因素,也是即将到来的医疗费用问题。因此,检测早期肾功能不全以及可以预测肾衰竭患者的死亡率的标记物长期以来一直是研究兴趣。尿液铸型,尿白蛋白/蛋白质水平和肾小球滤过率已在临床上使用了很长时间,在日本,将半胱氨酸蛋白酶抑制剂C和戊糖苷添加到这些经典标志物中已被批准用于诊断肾小球或肾小管功能障碍。然而,众所周知,这些常规标记物对早期检测和准确估计肾损伤的局限性。而且,它们对心血管事件和死亡率的预测价值是有限的。因此,新型的肾脏生物标志物必不可少。

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