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Cardiac sympathetic activity and left ventricular dyssynchrony - An old and new issue

机译:心脏交感神经活动与左心室不同步-新旧问题

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摘要

Cardiac sympathetic activity in the failing heart is both an old and a new issue. Classically in the heart, sympathetic activation results in an increased heart rate, more forceful contraction, and enhanced atrioventricular conduction, whereas the primary effect of the parasympathetic system is on heart rate regulation. Patients with heart failure show activation of the sympathetic nerve system, as reflected by increased plasma norepinephrine levels. As a consequence, a higher concentration of norepinephrine is present in the sympathetic cleft, leading to chronic stimulation and downregu-lation of myocardial beta-adrenoceptors.
机译:心脏衰竭中的心脏交感神经活动既是老问题,也是新问题。经典地在心脏中,交感神经的激活导致心率增加,更强烈的收缩和房室传导的增强,而副交感神经系统的主要作用是调节心率。心力衰竭患者表现出交感神经系统的激活,如血浆去甲肾上腺素水平升高所反映。结果,交感性裂隙中存在较高浓度的去甲肾上腺素,导致慢性刺激和心肌β-肾上腺素受体的下调。

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