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Epidemiology of arrhythmias and sudden cardiac death in Asia

机译:亚洲心律失常和心脏猝死的流行病学

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摘要

Cardiac arrhythmias are cardiac rhythm disorders that comprise an important epidemiological and public health problem. Cardiac arrhythmias are significantly associated with increased risks of cardiovascular complications and sudden death, consequently leading to decreased quality of life, disability, high mortality, and healthcare expense. Atrial fibrillation (AF) is the most common sustained arrhythmia, and has been further increasing with the aging of society. Although the prevalence is relatively lower in Asians than in Westerners, the prognostic impacts on stroke and mortality in Asians are comparable. Sudden cardiac death (SCD) occurs in approximately 40 cases per 100,000 persons annually in each country of Asia. Most cases are caused by myocardial infarction and ventricular fibrillation in out-of-hospital cardiac arrest cases, but the proportion of myocardial infarction is lower in Asia than in Western countries. The primary electrophysiological disorders related to channelopathies, such as long QT syndrome, short QT syndrome, Brugada syndrome, early repolarization syndrome, and catecholaminergic polymorphic ventricular tachycardia, are estimated to be responsible for 10% of SCDs. Implantable cardioverter-defibrillator implantation has become established as an effective secondary prevention for SCD, and numbers have been increasing annually worldwide. New insights into arrhythmic diseases have been emerging from epidemiological, clinical, and genetic research, and contribute to improvements in diagnosis and prognosis.
机译:心脏心律不齐是一种心律失常,包括重要的流行病学和公共卫生问题。心脏心律不齐与心血管并发症和猝死的风险增加显着相关,因此导致生活质量下降,残疾,高死亡率和医疗费用下降。心房纤颤(AF)是最常见的持续性心律不齐,并且随着社会的老龄化而进一步增加。尽管亚洲人的患病率比西方人低,但对亚洲人中风和死亡率的预后影响是可比的。在亚洲每个国家/地区,每年每10万人中约有40例发生心源性猝死。在院外心脏骤停病例中,大多数病例是由心肌梗塞和心室纤颤引起的,但亚洲的心肌梗塞比例低于西方国家。据估计,与通道病变相关的原发性电生理疾病,如长QT综合征,短QT综合征,Brugada综合征,早期复极化综合征和儿茶酚胺能性多形性室性心动过速,占SCD的10%。植入式心脏复律除颤器植入已被确定为SCD的有效二级预防,并且在世界范围内,其数量每年都在增加。从流行病学,临床和基因研究中发现了关于心律失常疾病的新见解,它们有助于诊断和预后的改善。

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