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首页> 外文期刊>Circulation journal >Angiotensin-converting enzyme inhibitor therapy inhibits the progression from paroxysmal atrial fibrillation to chronic atrial fibrillation.
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Angiotensin-converting enzyme inhibitor therapy inhibits the progression from paroxysmal atrial fibrillation to chronic atrial fibrillation.

机译：血管紧张素转换酶抑制剂治疗抑制了阵发性房颤向慢性心房颤动的发展。

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Background Atrial fibrillation is a progressive disease, which in the paroxysmal form (PAF) becomes more frequent and finally becomes chronic (CAF). A retrospective analysis of patients with PAF was conducted to examine the hypothesis that angiotensin-converting enzyme inhibitors (ACEI) will prevent the progression to CAF. Methods and Results On the basis of their treatment, 95 patients with PAF were divided into 2 groups: 42 patients treated with ACEI for hypertension throughout the period of treatment and follow-up (ACEI group) and 53 patients not given ACEI (non-ACEI group). Cardiac rhythms were assessed either from the medical records or the electrocardiograms recorded every 2-4 weeks at follow-up visits. The mean follow-up time was 8.3+/-3.5 years. There was no significant difference in the use of antiarrhythmic drugs, left atrial diameter or left ventricular ejection fraction between the 2 groups. The Kaplan-Meier curve for the time to occurrence of CAF showed a lower incidence of CAF in the ACEIgroup and demonstrated that the 5-year probability for persistence of PAF without progression to CAF was 88.3%, but 47.5% in the non-ACEI group. Conclusions These results indicate that ACEI will prevent progression from PAF to CAF. (Circ J 2005; 69: 671 - 676).
机译：背景技术心房颤动是一种进行性疾病，以阵发性形式（PAF）变得更加频繁，最终变为慢性（CAF）。对PAF患者进行了回顾性分析，以检查血管紧张素转化酶抑制剂（ACEI）会阻止发展为CAF的假说。方法和结果根据治疗方法，将95例PAF患者分为两组：42例在治疗和随访期间接受ACEI高血压治疗的患者（ACEI组）和53例未接受ACEI的患者（非ACEI）组）。在随访期间每2-4周从病历或心电图中评估心脏节律。平均随访时间为8.3 +/- 3。5年。两组之间在使用抗心律失常药物，左心房直径或左心室射血分数方面无显着差异。发生CAF的时间的Kaplan-Meier曲线显示ACEI组中CAF的发生率较低，并证明了5年持续发展为无CAF的PAF持续性的概率为88.3％，而非ACEI组为47.5％。 。结论这些结果表明，ACEI可以阻止PAF向CAF的发展。 （Circ J 2005; 69：671-676）。

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