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首页> 外文期刊>Circulation journal >Assessment of global and regional left ventricular function by electrocardiographic gated N-13 ammonia positron emission tomography in patients with coronary artery disease.
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Assessment of global and regional left ventricular function by electrocardiographic gated N-13 ammonia positron emission tomography in patients with coronary artery disease.

机译：通过心电门控N-13氨正电子发射断层扫描评估冠心病患者的整体和区域左心室功能。

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摘要

BACKGROUND: Electrocardiographic gated 13N-ammonia positron emission tomography (PET) enables simultaneous assessment of myocardial blood flow and left ventricular (LV) function. The aim of this study was to assess the accuracy of gated 13N-ammonia PET for evaluating global and regional LV function in patients with coronary artery disease (CAD) in comparison with conventional left ventriculography (LVG). METHODS AND RESULTS: Fifty-four patients with CAD underwent gated 13N-ammonia PET and LVG. The LV end-diastolic and end-systolic volumes (LVEDV, LVESV) and ejection fraction (LVEF) by gated 13N-ammonia PET were calculated using Cedars-Sinai automated quantitative gated single photon emission computed tomography (QGS) and compared with those obtained by LVG. The regional wall motion (RWM) was visually scored, and compared with that on LVG. There were good correlations between the 2 methods for LVEF, LVEDV and LVESV (R=0.828, R=0.821 and R=0.874 respectively). The RWM assessed by gated 13N-ammonia PET also agreed well with that by LVG (complete agreement was 70.4%, kappa=0.58). CONCLUSIONS: Gated 13N-ammonia PET combined with QGS works reasonably well for the assessment of both global and regional LV function in CAD patients, although additional calibration may be necessary.
机译：背景：心电门控的13N氨正电子发射断层扫描（PET）可同时评估心肌血流和左心室（LV）功能。这项研究的目的是评估与常规左心室造影术（LVG）相比，门控13N氨PET评估冠状动脉疾病（CAD）患者的整体和区域LV功能的准确性。方法和结果：54例CAD患者接受门控13N氨PET和LVG。使用Cedars-Sinai自动定量门控单光子发射计算机断层扫描（QGS）计算门控13N氨PET的左室舒张末期容积和收缩末期容积（LVEDV，LVESV）和射血分数（LVEF）并与通过LVG。视觉评估区域壁运动（RWM），并与LVG进行比较。 LVEF，LVEDV和LVESV的两种方法之间具有良好的相关性（分别为R = 0.828，R = 0.821和R = 0.874）。封闭13N氨PET评估的RWM也与LVG评估的RWM非常吻合（完全一致率为70.4％，kappa = 0.58）。结论：门控13N氨PET结合QGS可以很好地评估CAD患者的整体和局部左室功能，尽管可能需要额外的校准。

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