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首页> 外文期刊>Circulation journal >Use of Bepridil in Combination With Ic Antiarrhythmic Agent in Converting Persistent Atrial Fibrillation to Sinus Rhythm
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Use of Bepridil in Combination With Ic Antiarrhythmic Agent in Converting Persistent Atrial Fibrillation to Sinus Rhythm

机译：苯必得尔与抗心律失常药物联合使用可将持续性心房颤动转变为窦性心律

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Background It has been reported that bepridil is as good as amiodarone in converting persistent atrial fibrillation (AF) to sinus rhythm (SR). The conversion effect of bepridil alone is not always satisfactory, however. The efficacy of pharmacological cardioversion by the combination of bepridil and a class Ic antiarrhythmic drug for persistent AF is studied. Methods and Results The participants comprised 37 consecutive patients in whom pharmacological cardioversion was conducted to treat persistent AF (duration 22.5+-29.6 months). Each patient first received a class la or Ic antiarrhythmic drug, then bepridil alone, then a combined therapy of bepridil at 200 mg/day with a class Ic antiarrhythmic drug at a routine dose. Unaccompanied use of any of the antiarrhythmic drugs achieved pharmacological cardioversion in 14 (38%) of the 37 patients (single therapy group), whereas SR was restored by combination of bepridil and a class Ic antiarrhythmic drug in 22 (combined therapy group) of the remaining 23 patients. The duration of AF was significantly longer in the combined therapy group than in the single therapy group (28.3+-31.0vs 7.3+4.1 months). Conclusion Combined therapy of bepridil and a class Ic antiarrhythmic drug is efficient for pharmacological cardioversion of refractory long-lasting persistent AF.
机译：背景技术据报道，在将持续性心房纤颤（AF）转换为窦律（SR）方面，贝普利尔与胺碘酮一样好。但是，单独使用苯普地尔的转化效果并不总是令人满意的。研究了贝必利和Ic类抗心律不齐药物联合使用对持续性房颤的药理心脏复律功效。方法和结果参与者包括37例连续患者，进行了药物复律治疗持续性AF（持续时间22.5 + -29.6个月）。每位患者首先接受1a或Ic类抗心律不齐药物，然后单独使用贝普利尔，然后按常规剂量将200mg /天的苯必得尔与Ic类抗心律不齐药物联合治疗。在37例患者（单药治疗组）中，无人使用任何抗心律失常药物可实现14例（38％）的药理性心脏复律，而在22例（联合治疗组）中，贝必得和Ic类抗心律不齐药物的联合使用可恢复SR其余23例。联合治疗组的房颤持续时间明显长于单一治疗组（28.3 + -31.0vs 7.3 + 4.1个月）。结论贝必利与Ic类抗心律不齐药物联合治疗对难治性持久性持续性房颤的药物复律是有效的。

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