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首页> 外文期刊>Circulation journal >Beneficial Effect of Perindopril on Cardiac Sympathetic Nerve Activity and Brain Natriuretic Peptide in Patients With Chronic Heart Failure-Comparison With Enalapril-
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Beneficial Effect of Perindopril on Cardiac Sympathetic Nerve Activity and Brain Natriuretic Peptide in Patients With Chronic Heart Failure-Comparison With Enalapril-

机译：培哚普利对慢性心力衰竭患者心脏交感神经活性和脑钠肽的有益作用-与依那普利比较

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Background In patients with chronic heart failure (CHFJ, it remains unclear whether perindopril is more car-dioprotective than enalapril. Methods and Results Forty-five stable CHF outpatients undergoing conventional therapy including enalapril therapy were randomized to 2 groups [group 1 (n=24): continuous enalapril treatment; group H (n=21): enalapril was changed to perindopril]. Cardiac sympathetic nerve activity was evaluated using cardiac ~(123)I-metaiodoben-zylguanidine (MIBG) scintigraphy, hemodynamic parameters and neurohumoral factors before and 6 months after treatment. There was no difference in baseline characteristics between the 2 groups. In group I, there were no changes in MIBG parameters, left ventricular ejection fraction (LVEF) or plasma level of brain natriuretic peptide (BNP). In contrast, in group II the delayed heart/mediastinum count ratio was significantly increased (2.0+-0.07 vs 2.15+0.07, p=0.013) and the washout rate was significantly decreased (33.0+-1.4 vs 30.5+-1.2, p=0.030) after 6 months compared with the baseline value. In addition, LVEF was significantly increased and the plasma BNP level was significantly decreased. Conclusion These findings suggest that for the treatment of CHF, perindopril is superior to enalapril with respect of cardiac sympathetic nerve activity and BNP.
机译：背景和方法：结果：在慢性心力衰竭（CHFJ）患者中，培哚普利是否比依那普利更具抗心脏保护作用尚不清楚。方法和结果将45名接受常规治疗（包括依那普利）的稳定CHF门诊患者随机分为两组[第1组（n = 24 ）：依那普利连续治疗; H组（n = 21）：依那普利改为培哚普利]。使用心脏〜（123）I-甲氧代本苯甲酰胍（MIBG）显像，心脏血流动力学参数和神经体液因素评估心脏交感神经活动治疗后6个月，两组之间的基线特征没有差异;在第一组中，MIBG参数，左室射血分数（LVEF）或脑钠肽（BNP）的血浆水平没有变化。在第二组中，延迟的心脏/纵隔计数比显着增加（2.0 + -0.07 vs 2.15 + 0.07，p = 0.013），洗脱率显着降低（33.0 + -1.4 vs.与基线值相比，在6个月后为30.5 + -1.2，p = 0.030）。此外，LVEF显着升高，血浆BNP水平显着降低。结论这些发现表明，在心脏交感神经活性和BNP方面，培哚普利优于依那普利对CHF的治疗。

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