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首页> 外文期刊>Circulation journal >Significance of Early Onset and Progressive Increase of Activation Delay During Premature Stimulationin Brugada Syndrome
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Significance of Early Onset and Progressive Increase of Activation Delay During Premature Stimulationin Brugada Syndrome

机译:Brugada综合征早期刺激早期发作和激活延迟的逐步增加的意义

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Background: The relationship between the activation delay during programmed stimulation and the inducibility of ventricular fibrillation (VF) and filtered QRS duration on signal-averaged ECG (SAECG) were assessed in patients with Brugada syndrome (BS).Methods and Results: The activation delay was assessed using the interval between the stimulus and the QRS complex during programmed stimulation in 25 patients with BS and 10 with idiopathic ventricular tachycardia (controls). The mean increase of delay (MID) was used to characterize the conduction curves. The filtered QRS duration (fQRSd) in leads V2 (RfQRSd) and V5 (LfQRSd) were also evaluated using SAECG. Both MIDs at the right ventricular outflow tract (RVOT) were significantly greater in symptomatic and asymptomatic BS patients than in the control group (symptomatic, 7.1?7ms vs control, 2.5?2ms, P<0.001, asymptomatic, 7.3?3ms vs control, P<0.001, respectively). The MID correlated with the His-ventricular interval; however, there were no significant correlations between the MID and RfQRSd or RfQRSd-LfQRSd.Conclusions: The MID, which indicates an increase of the St-QRS during premature stimulation, was much greater in patients with BS (regardless of clinical symptoms) than in the control group, especially in the RVOT, which might be related to the easy inducibility of VF from the RVOT.
机译:背景:在布鲁加达综合征(BS)患者中,评估了程序性刺激期间的激活延迟与心室纤颤(VF)的可诱导性和经滤波的QRS持续时间对信号平均ECG(SAECG)的关系。使用25位BS患者和10位特发性室性心动过速(对照)的程序性刺激过程中的刺激和QRS复杂度之间的间隔来评估心律失常。平均延迟增加(MID)用于表征传导曲线。还使用SAECG评估了引线V2(RfQRSd)和V5(LfQRSd)中的已过滤QRS持续时间(fQRSd)。有症状和无症状BS患者的右心室流出道(RVOT)的两个MID均显着高于对照组(有症状的7.1?7ms vs对照,2.5?2ms,P <0.001,无症状的7.3?3ms与对照组相比, P <0.001)。 MID与心室间隔有关;结论:MID,表明过早刺激过程中St-QRS的增加,与BS患者(无论临床症状如何)相比,MID与RfQRSd或RfQRSd-LfQRSd之间无显着相关性。对照组,特别是在RVOT中,这可能与RVOT容易诱发VF有关。

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