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首页> 外文期刊>Circulation journal >Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats.
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Effects of a pure alpha/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats.

机译：单纯的α/β-肾上腺素能受体阻滞剂对单克尿茶碱诱导的大鼠右心室肥大的肺动脉高压的作用。

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BACKGROUND: It is unclear how much the sympathetic nervous system is involved in the development of pulmonary arterial hypertension (PAH). The present study examined whether or not a pure alpha/beta-adrenergic receptor blocker (arotinolol) could prevent the development of PAH and right ventricular hypertrophy (RVH) in a rat model of monocrotaline (MCT)-induced PAH. METHODS AND RESULTS: The heart rate, arterial blood pressure (BP), left ventricular pressure, pulmonary artery pressure (PAP), and right ventricular pressure (RVP) were measured after administration of arotinolol or saline for 2 weeks. Ventricular weight and myocyte size were also measured. Mean PAP was increased less in the arotinolol group (n=6), (53 +/-9 vs 21 +/-2 mmHg in the control (n=6); P<0.01). Systolic RVP was also less in the arotinolol group (41 +/-3 vs 91 +/-14 mmHg in the control, P<0.05) without differences in BP. It also significantly reduced the RV/body weight ratio (0.58 +/-0.01 vs 0.77 +/-0.04 mg/g; P<0.01). Furthermore, the myocyte width was significantly decreased in the arotinolol group. CONCLUSIONS: The pure alpha/beta-blocker arotinolol prevented the progression of MCT-induced PAH and RVH in rats, suggesting that sympathetic nervous activation might play a role in the development of PAH.
机译：背景：目前尚不清楚交感神经系统参与了肺动脉高压（PAH）的发展。本研究检查了纯α/β-肾上腺素受体阻滞剂（arotinolol）是否可以预防由单芥子碱（MCT）诱发的PAH大鼠模型中PAH和右心室肥大（RVH）的发展。方法和结果：在服用阿托洛尔或生理盐水2周后，测量心率，动脉血压（BP），左心室压力，肺动脉压力（PAP）和右心室压力（RVP）。还测量了心室重量和肌细胞大小。阿罗替洛尔组的平均PAP升高较少（n = 6）（对照组为53 +/- 9 vs 21 +/- 2 mmHg（n = 6）; P <0.01）。阿替洛尔组的收缩压RVP也较低（对照组为41 +/- 3 vs 91 +/- 14 mmHg，P <0.05），血压无差异。它还显着降低了RV /体重比（0.58 +/- 0.01与0.77 +/- 0.04 mg / g; P <0.01）。此外，阿替洛尔组的心肌细胞宽度明显减少。结论：纯的α/β-受体阻滞剂阿罗替洛尔阻止了MCT诱导的大鼠PAH和RVH的进展，提示交感神经激活可能在PAH的发生中起作用。

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