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首页> 外文期刊>Circulation journal >Is this a philosophic issue? Do patients with drug-induced Brugada type ECG have poor prognosis? (Pro).
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Is this a philosophic issue? Do patients with drug-induced Brugada type ECG have poor prognosis? (Pro).

机译：这是一个哲学问题吗？药物性Brugada型ECG患者预后是否不良？ （专业版）。

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摘要

Brugada syndrome (BS) has an intermittent or concealed type, which can be unmasked by the sodium (Na(+))-channel-blocker challenge test. The appropriate risk stratification of patients with a drug-induced Brugada-type electrocardiographic (ECG), especially those without a history of syncope or aborted sudden cardiac death, remains unclear. The prognosis of patients with BS depends on the clinical type, cardiac arrest, syncope or if asymptomatic. The ratio of the asymptomatic group varies from 56.9% to 63.6% and, furthermore, their annual cardiac event rate is relatively lower at 0.24-3.6% compared with the cardiac arrest group. Patients with a drug-induced Brugada-type ECG have a poor prognosis if they had a history of ventricular fibrillation (VF) or aborted sudden cardiac death, because their risk becomes similar to that of patients with spontaneous Brugada-type ECG. They have the disturbance of the Na(+)-channel and the electrophysiologic substrate of VF, proven by the high inducibility of VF by stimulation test even in patients without spontaneous VF. Spontaneous VF will never occur if there is no VF substrate. Implantable cardioverter-defibrillators will certainly protect them, so patients with a drug-induced Brugada-type ECG, even without a history of VF or aborted sudden cardiac death, should be considered to have a poor prognosis.
机译：Brugada综合征（BS）具有间歇性或隐性类型，可以通过钠（Na（+））-通道阻滞剂攻击试验来掩盖。尚不清楚药物诱发的Brugada型心电图（ECG）患者的适当危险分层，尤其是没有晕厥病史或心脏骤停中止的患者。 BS患者的预后取决于临床类型，心脏骤停，晕厥或无症状。无症状组的比率从56.9％到63.6％不等，此外，与心脏骤停组相比，他们的年度心脏事件发生率相对较低，为0.24-3.6％。具有药物性Brugada型ECG的患者如果有心室颤动（VF）病史或中止心源性猝死，则预后较差，因为他们的风险与自发性Brugada型ECG的风险相似。它们具有Na（+）通道和VF的电生理底物的干扰，通过刺激测试对VF的高诱导性证明，即使在没有自发性VF的患者中也是如此。如果没有VF基材，则自发性VF将永远不会发生。植入式心脏复律除颤器一定会为他们提供保护，因此，即使没有VF病史或心脏骤停中止，药物诱导的Brugada型ECG患者也应被认为预后较差。

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