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首页> 外文期刊>Journal de gyne?cologie, obste?trique et biologie de la reproduction. >Use of misoprostol for induction of labor in case of fetal death or termination of pregnancy during second or third trimester of pregnancy: Efficiency, dosage, route of administration, side effects, use in case of uterine scar [Utilisation du misoprostol pour l'induction du travail en cas de MIU ou d'IMG au deuxième ou au troisième trimestre de la grossesse: efficacité, posologie, voie d'administration, effets secondaires, utilisation en cas d'utérus cicatriciel]
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Use of misoprostol for induction of labor in case of fetal death or termination of pregnancy during second or third trimester of pregnancy: Efficiency, dosage, route of administration, side effects, use in case of uterine scar [Utilisation du misoprostol pour l'induction du travail en cas de MIU ou d'IMG au deuxième ou au troisième trimestre de la grossesse: efficacité, posologie, voie d'administration, effets secondaires, utilisation en cas d'utérus cicatriciel]

机译：米索前列醇在胎儿死亡或妊娠中期或妊娠中期终止妊娠时引产：功效，剂量，给药途径，副作用，子宫疤痕使用[米索前列醇用于引产MIU或IMG在妊娠中期或中期进行的工作：功效，剂量，给药途径，副作用，子宫有疤痕的情况下使用]

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Objective Study, based on the literature, of the use of misoprostol for induction of labor in cases of second or third trimester fetal death or termination of pregnancy and define the different mode of administration. Materials and methods Bibliographic review using the Medline and Pubmed databases and the guidelines of the international professional societies. Selection of papers in French and English. Keywords used: misoprostol, termination of pregnancy, mid and third trimester, scarred uterus, previous cesarean section, uterine rupture. Results Misoprostol is effective for induction of labor in case of second or third fetal death or termination of pregnancy. Comparing to oral route, vaginal route reduces the induction-expulsion time and the rate of patients remaining undelivered in the first 24 hours without increasing side effects. Oral route is a possible alternative if preferred by the patient. Sublingual route seems interesting but data are limited. The use of moderate doses (800-2400 μg/day) every 3 to 6 hours seems to be the best compromise between efficiency and tolerance. It is not possible to recommend a specific dosing schedule. The risk of uterine rupture in case of previous cesarean section justifies the use of minimum effective dose for these patients. In this case, it is recommended not to exceed a dose of 100 μg for each dose. The induction-birth period and doses of misoprostol required to induce labor are reduced when combined with mifepristone administered 36 to 48 hours before. Conclusion Misoprostol is effective and safe for induction of labor in case of second or third trimester fetal death or termination of pregnancy.
机译：基于文献的客观研究，用于在中，晚期胎儿死亡或终止妊娠的情况下使用米索前列醇引产，并定义了不同的给药方式。材料和方法使用Medline和Pubmed数据库以及国际专业学会的指南进行书目审查。法语和英语论文选集。使用的关键词：米索前列醇，终止妊娠，中期和中期，子宫疤痕，先前的剖宫产，子宫破裂。结果米索前列醇在第二或第三胎死亡或终止妊娠的情况下对引产有效。与口服途径相比，阴道途径减少了诱导驱逐时间，并减少了前24小时内未分娩的患者比率，而没有增加副作用。如果患者愿意，可以采用口服途径。舌下途径似乎很有趣，但数据有限。每3至6小时使用中等剂量（800-2400μg/天）似乎是效率和耐受性之间的最佳折衷方案。无法建议特定的给药时间表。在先前剖宫产的情况下发生子宫破裂的风险证明对这些患者使用最小有效剂量是合理的。在这种情况下，建议每次剂量不要超过100μg。当与米非司酮联用前36至48小时给药，诱导分娩期和米索前列醇诱导分娩所需的剂量减少。结论米索前列醇在中，晚期胎儿死亡或终止妊娠时引产安全有效。

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