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首页> 外文期刊>Circulation journal >Clinical characteristics of patients with kawasaki disease and levels of peripheral endothelial progenitor cells and blood monocyte subpopulations.
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Clinical characteristics of patients with kawasaki disease and levels of peripheral endothelial progenitor cells and blood monocyte subpopulations.

机译：川崎病患者的临床特征以及外周内皮祖细胞和血液单核细胞亚群的水平。

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BACKGROUND: Coronary sequelae that persist after Kawasaki disease (KD) have been associated with coronary vascular events in adolescents and young adults. The aim of this study was to investigate the relationship between coronary sequelae late after KD and circulating endothelial progenitor cells (EPCs), as a marker of vascular repair, or monocyte subsets as a marker of inflammation. METHODS AND RESULTS: The 31 KD patients were divided into 3 groups according to the type of coronary artery lesion (CAL): group 1 consisted of 14 patients with persistent aneurysm; group 2 consisted of 9 patients with regressed aneurysms; group 3 included 8 KD patients with normal coronary arteries from disease onset. The control group (group 4) consisted of 10 healthy subjects. Flow cytometric analysis was used to quantify circulating EPCs defined as CD34(+)KDR(+) cells and 2 distinct monocyte subsets (CD14(+)CD16(+) and CD14(+)CD16(-)). The number of EPCs in group 1 and group 2 was significantly decreased compared with group 4. In contrast, neither the number of CD14(+)CD16(+) monocytes nor that of CD14(+)CD16(-) monocytes was significantly different among the 4 groups. Finally, there were not any significant relationship between the numbers of EPCs and the 2 monocyte subsets. CONCLUSIONS: There are lower numbers of EPCs in the chronic phase of KD, irrespective of both CAL formation and monocyte subsets.
机译：背景：川崎病（KD）后持续存在的冠状后遗症与青少年和年轻人的冠状血管事件有关。这项研究的目的是调查KD后晚期冠状动脉后遗症与循环内皮祖细胞（EPC）作为血管修复的标志物，或单核细胞亚群作为炎症标志物之间的关系。方法和结果：31例KD患者根据冠状动脉病变（CAL）的类型分为3组：第1组由14例持续性动脉瘤患者组成。第2组包括9例动脉瘤消退;第3组包括8名KD患者，其疾病发作后冠状动脉正常。对照组（第4组）由10名健康受试者组成。流式细胞仪分析用于定量定义为CD34（+）KDR（+）细胞和2个不同的单核细胞亚群（CD14（+）CD16（+）和CD14（+）CD16（-））的循环EPC。与第4组相比，第1组和第2组的EPC数量明显减少。相比之下，CD14（+）CD16（+）单核细胞的数量和CD14（+）CD16（-）单核细胞的数量均无显着差异。 4组。最后，EPC的数量与2个单核细胞亚群之间没有显着关系。结论：KD慢性期的EPC数量较少，而与CAL形成和单核细胞亚群无关。

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