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首页> 外文期刊>Circulation journal >Cardiac iodine-123 metaiodobenzylguanidine ( 123I-MIBG) scintigraphy parameter predicts cardiac and cerebrovascular events in type 2 diabetic patients without structural heart disease
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Cardiac iodine-123 metaiodobenzylguanidine ( 123I-MIBG) scintigraphy parameter predicts cardiac and cerebrovascular events in type 2 diabetic patients without structural heart disease

机译：心脏碘123碘碘苄胍（123I-MIBG）闪烁显像参数可预测无结构性心脏病的2型糖尿病患者的心脏和脑血管事件

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Background: Cardiac iodine-123 metaiodobenzylguanidine ( 123I-MIBG) scintigraphy is an established method of assessment of cardiovascular sympathetic function. The aim of the present study was to investigate the long-term cardiovascular predictive value of cardiac 123I-MIBG scintigraphy parameters in Japanese type 2 diabetic patients without structural heart disease. Methods and Results: Cardiac 123I-MIBG scintigraphy in 108 patients with type 2 diabetes who did not have structural heart disease, was evaluated. The washout rate (WR) was considered enhanced if it was ≥40%. Accurate follow-up information for 4.6 years was obtained in 54 enhanced WR patients (27 male; mean age, 61±11 years) and in 54 sex- and age-matched preserved WR patients (27 male; mean age, 61±10 years). Major adverse cardiac and cerebrovascular events (MACCE) were investigated. During follow-up, 10 enhanced WR patients developed MACCE including cardiac death, coronary revascularization, stroke, and congestive heart failure, while MACCE occurred in only 3 male patients. The Kaplan-Meier curves indicated that enhanced WR patients had higher incidence of MACCE than those with preserved WR (P0.05). Cox proportional hazards regression analysis showed that age and enhanced WR were independently associated with the incidence of MACCE (hazard ratio, 4.06; 95% confidence interval: 1.194-18.76, P=0.0237). Conclusions: Abnormal WR of cardiac 123I-MIBG scintigraphy at baseline has long-term cardiovascular predictive value in Japanese patients with type 2 diabetes without structural heart disease.
机译：背景：心脏碘123碘碘苄基胍（123I-MIBG）闪烁显像是评估心血管交感神经功能的既定方法。本研究的目的是调查在无结构性心脏病的日本2型糖尿病患者中，心脏123I-MIBG闪烁显像参数的长期心血管预测价值。方法和结果：评价了108例无结构性心脏病的2型糖尿病患者的心脏123I-MIBG显像。如果≥40％，则认为洗脱率（WR）增强。在54名增强型WR患者（27名男性;平均年龄，61±11岁）和54名性别和年龄相匹配的保留WR患者（27名男性;平均年龄，61±10岁）中获得了4.6年的准确随访信息。 ）。重大不良心脏和脑血管事件（MACCE）进行了调查。在随访期间，有10例增强型WR患者发生了MACCE，包括心脏死亡，冠状动脉血运重建，中风和充血性心力衰竭，而MACCE仅在3例男性患者中发生。 Kaplan-Meier曲线表明，WR增强患者比WR保留者有更高的MACCE发生率（P <0.05）。 Cox比例风险回归分析显示年龄和WR增加与MACCE的发生率独立相关（风险比4.06; 95％置信区间：1.194-18.76，P = 0.0237）。结论：对于没有结构性心脏病的日本2型糖尿病患者，基线时123I-MIBG闪烁体心线描记的异常WR具有长期心血管预测价值。

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