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首页> 外文期刊>Circulation journal >Clinical signifcance of abnormal relaxation pattern of the transmitral flow velocity waveform in older patients with preserved left ventricular ejection fraction
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Clinical signifcance of abnormal relaxation pattern of the transmitral flow velocity waveform in older patients with preserved left ventricular ejection fraction

机译：保留左心室射血分数的老年患者传输流速波形异常松弛模式的临床意义

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Background: The pathophysiology of abnormal relaxation pattern in the transmitral flow (TMF) velocity waveform has not been fully elucidated. Methods and Results: A total of 173 patients who underwent comprehensive Doppler echocardiography and diagnostic cardiac catheterization for coronary artery disease were enrolled in the study. Peak early and late diastolic TMF velocities (E and A, respectively) were measured. Minimum left ventricular (LV) pressure; LV pre-A wave pressure (surrogate of mean left atrial [LA] pressure); time constant (τ) of LV pressure decay; and LV ejection fraction (LVEF) were calculated. Patients with E/A ratio <1.0 and LVEF ≥50% were enrolled. Patients with τ ≥48 ms and those with τ <48 ms were compared. The 2 groups had no significant differences in E or E/A. Minimum LV pressure (6.9±2.2 mmHg vs. 3.6±2.9 mmHg, P<0.0001) and LV pre-A wave pressure (9.5±2.4 mmHg vs. 6.1±3.0 mmHg, P<0.0001) were significantly higher in patients with τ ≥48 ms compared to those with τ <48 ms, but the difference between the LV pre-A and minimum LV pressures was similar between the groups (2.6±1.4 mmHg vs. 2.5±1.5 mmHg, P=0.89). Conclusions: Proportional elevations in minimum LV and pre-A pressures, due to deteriorated LV relaxation, resulted in no changes in the pressure gradient between the LA and LV in early diastole, E, or E/A.
机译：背景：传输流（TMF）速度波形中异常松弛模式的病理生理学尚未得到充分阐明。方法和结果：共纳入173例接受了多普勒超声心动图检查和诊断性导管检查的冠心病患者。测量了舒张期早期和晚期TMF的峰值速度（分别为E和A）。最小左心室（LV）压力; LV pre-A波压（平均左心房[LA]压力的替代）;低压压力衰减的时间常数（τ）;计算左室射血分数（LVEF）。入选E / A <1.0且LVEF≥50％的患者。比较了τ≥48 ms和τ＜48 ms的患者。两组的E或E / A无显着差异。 τ≥患者的最低LV压力（6.9±2.2 mmHg vs.3.6±2.9 mmHg，P <0.0001）和LV pre-A波压（9.5±2.4 mmHg vs. 6.1±3.0 mmHg，P <0.0001）明显更高与τ<48 ms的压力相比，压力为48 ms，但是两组之间的LV pre-A和最低LV压力之间的差异相似（2.6±1.4 mmHg对2.5±1.5 mmHg，P = 0.89）。结论：由于左心室舒张恶化，最小左室压力和前A压力成比例升高，导致舒张早期，E或E / A中左室和左室之间的压力梯度没有变化。

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