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首页> 外文期刊>Circulation journal >Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction
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Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction

机译：急性心肌梗死后低水平的血清n-3多不饱和脂肪酸与无心衰生存期较差有关

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Background: Intake of long-chain n-3 polyunsaturated fatty acids (n-3 PUFA), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), is associated with a lower risk of atherosclerotic cardiovascular events, particularly acute myocardial infarction (AMI). However, limited data are available regarding the association between serum n-3 PUFA levels and heart failure (HF) events in survivors of AMI. Methods and Results: We evaluated whether serum DHA and EPA levels were associated with HF-free survival and HF hospitalization rates after AMI. A total of 712 patients were divided into 3 groups according to their tertile serum levels of DHA and EPA (Low, Middle, and High). Propensity-score-stratified Cox regression analysis revealed that DHA- and EPA-Low groups presented statistically significant worse HF-free survival (hazard ratio (HR) 1.68, 95% confidence interval (CI) 1.03-2.72, P=0.0358, and HR 1.69, 95% CI 1.05-2.72, P=0.0280, respectively), with the EPALow group having a higher risk of HF hospitalization (HR 2.40, 95% CI 1.21-4.75, P=0.0097) than the DHA-Low group (HR 1.72, 95% CI 0.86-3.45, P=0.1224). The relationship between a low DHA or EPA level and decreased HF-free survival was almost common to all subgroups; however, the effect of low serum EPA on HF hospitalization was prominent in male patients, and those with low levels of high-density lipoprotein cholesterol or without statin therapy. Conclusions: Low levels of circulating n-3 PUFA are associated with decreased HF-free survival in post-AMI patients.
机译：背景：摄入长链n-3多不饱和脂肪酸（n-3 PUFA），包括二十二碳六烯酸（DHA）和二十碳五烯酸（EPA），与降低动脉粥样硬化性心血管事件，特别是急性心肌梗塞（AMI）的风险有关）。但是，关于AMI幸存者的血清n-3 PUFA水平与心力衰竭（HF）事件之间相关性的数据有限。方法和结果：我们评估了AMI后血清DHA和EPA水平是否与无HF生存率和HF住院率相关。共有712位患者根据DHA和EPA的血清水平（低，中和高）分为3组。倾向得分分层Cox回归分析显示，DHA和EPA低组在统计学上显示无HF生存较差（危险比（HR）1.68、95％置信区间（CI）1.03-2.72，P = 0.0358和HR）分别为1.69、95％CI 1.05-2.72，P = 0.0280），其中EPALow组比DHA-Low低组（HR）有更高的HF住院风险（HR 2.40，95％CI 1.21-4.75，P = 0.0097）。 1.72，95％CI 0.86-3.45，P ＝ 0.1224）。低DHA或EPA水平与无HF存活率降低之间的关系在所有亚组中几乎都是普遍的。然而，低血清EPA对HF住院的影响在男性患者以及高密度脂蛋白胆固醇水平低或未接受他汀类药物治疗的患者中尤为明显。结论：低水平的循环n-3 PUFA与AMI后患者的无HF存活期降低有关。

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