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首页> 外文期刊>Circulation journal >Impaired myocardial perfusion reserve in patients with fatty liver disease assessed by quantitative myocardial perfusion magnetic resonance imaging
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Impaired myocardial perfusion reserve in patients with fatty liver disease assessed by quantitative myocardial perfusion magnetic resonance imaging

机译：通过定量心肌灌注磁共振成像评估脂肪性肝病患者的心肌灌注储备受损

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Background: The purpose of this study was to determine whether the presence of fatty liver is associated with an alteration in myocardial perfusion reserve (MPR). Methods and Results: A retrospective analysis of 65 asymptomatic subjects who underwent both plain abdominal computed tomography and cardiac magnetic resonance imaging (MRI), and who had normal left ventricular wall motion, no regional myocardial ischemia and no myocardial scar on MRI was performed. Stress and rest myocardial perfusion MRI were analyzed by Patlak plot method to quantify myocardial blood flow (MBF) and MPR in 16 myocardial segments. Fatty liver was detected in 18 (28%) of the 65 subjects. No significant difference was found in rest-MBF between subjects with and without fatty liver (1.2±0.75 vs. 1.1±0.67 ml · min -1 · g -1, P=0.59). However, MPR was significantly lower in subjects with fatty liver than the non-fatty liver subjects (2.3±0.74 vs. 3.3±1.4, P0.001). Subjects with fatty liver had a higher prevalence of MPR 2.5 (78% vs. 38%, P0.005) and higher triglyceride levels (206±61 vs. 92±37 mg/dl, P0.001). Multivariate analysis revealed the presence of fatty liver as a significant predictor of reduced MPR with an odds ratio of 8.2 (P0.01). Conclusions: Nonalcoholic fatty liver disease is related to reduced MPR, suggesting impaired coronary microcirculation.
机译：背景：本研究的目的是确定脂肪肝的存在是否与心肌灌注储备（MPR）的改变有关。方法和结果：回顾性分析了65例无症状的受试者，他们均接受了平腹X线断层扫描和心脏磁共振成像（MRI）检查，并且左心室壁运动正常，无局部心肌缺血和无心肌疤痕。通过Patlak图法分析应激和静息心肌灌注MRI，以量化16个心肌节段的心肌血流量（MBF）和MPR。 65名受试者中有18名（28％）检测到脂肪肝。有脂肪肝和无脂肪肝的受试者之间的剩余MBF差异均无统计学意义（1.2±0.75 vs. 1.1±0.67 ml·min -1·g -1，P = 0.59）。然而，患有脂肪肝的受试者的MPR显着低于非脂肪肝的受试者（2.3±0.74 vs. 3.3±1.4，P <0.001）。患有脂肪肝的受试者的MPR <2.5患病率更高（78％比38％，P <0.005）和甘油三酸酯水平更高（206±61 vs. 92±37 mg / dl，P <0.001）。多变量分析显示，脂肪肝是MPR降低的重要预测指标，比值比为8.2（P <0.01）。结论：非酒精性脂肪性肝病与MPR降低有关，提示冠状动脉微循环受损。

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